A degradation fragment of type X collagen is a real-time marker for bone growth velocity.
A degradation fragment of type X collagen is a real-time marker for bone growth velocity.
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DOI：
10.1126/scitranslmed.aan4669
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发表时间：
2017-12-06
影响因子：
17.1
通讯作者：
Horton WA
中科院分区：
文献类型：
--
作者：
Coghlan RF;Oberdorf JA;Sienko S;Aiona MD;Boston BA;Connelly KJ;Bahney C;LaRouche J;Almubarak SM;Coleman DT;Girkontaite I;von der Mark K;Lunstrum GP;Horton WA
尽管生长速度作为儿童健康和发育的关键参数很重要，但它很难实时确定，因为骨骼生长缓慢，并且不存在准确检测非常小的生长增量的临床工具。我们报告发现了婴儿和儿童骨骼生长的标记物。 X 型胶原蛋白的完整三聚体非胶原蛋白 1 (NC1) 结构域（我们将其命名为 X 型胶原蛋白标记物 CXM）是软骨内骨化的降解副产物，与整体生长板活性成比例地释放到循环中。该标记对应于测量时的线性骨生长速率。根据年龄绘制的 CXM 血清浓度显示出类似于已确定的身高生长速度曲线的模式，并且与本研究中根据增量身高测量计算出的身高生长速度相关。 CXM 标记物一旦收集就稳定，可以在血清、血浆和干血斑中进行准确分析。 CXM 测试可能有助于监测儿科人群的生长，特别是患有遗传性和获得性生长障碍的婴儿和儿童对针对潜在生长障碍的干预措施的反应。 CXM 的用途可能会扩展到治疗其他疾病，例如骨折愈合、脊柱侧凸、关节炎或癌症。
Despite its importance as a key parameter of child health and development, growth velocity is difficult to determine in real timebecause skeletal growth is slowand clinical tools to accurately detect very small increments of growth do not exist. We report discovery of a marker for skeletal growth in infants and children. The intact trimeric noncollagenous 1 (NC1) domain of type X collagen, the markerwe designated as CXMfor Collagen X Marker, is a degradation by-product of endochondral ossification that is released into the circulation in proportion to overall growth plate activity. Thismarker corresponds to the rate of linear bone growth at timeofmeasurement. Serumconcentrations of CXMplotted against age showa pattern similar to well-established height growth velocity curves and correlate with height growth velocity calculated from incremental height measurements in this study. The CXM marker is stable once collected and can be accurately assayed in serum, plasma, and dried blood spots. CXMtestingmay be useful for monitoring growth in the pediatric population, especially responses of infants and children with genetic and acquired growth disorders to interventions that target the underlying growth disturbances. The utility of CXM may potentially extend to managing other conditions such as fracture healing, scoliosis, arthritis, or cancer.
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DOI：
10.1038/mtna.2014.49
发表时间：
2014-10-07
期刊：
Molecular therapy. Nucleic acids
影响因子：
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作者：
通讯作者：
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影响因子：
7.2
作者：
Long, Fanxin;Ornitz, David M.
通讯作者：
Ornitz, David M.
影响因子：
56.9
作者：
LAMPL, M;VELDHUIS, JD;JOHNSON, ML
通讯作者：
JOHNSON, ML
DOI：
10.1038/nrrheum.2014.164
发表时间：
2015-01
期刊：
Nature reviews. Rheumatology
影响因子：
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作者：
通讯作者：
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DOI：
10.1038/nrendo.2014.78
发表时间：
2014-08
期刊：
Nature reviews. Endocrinology
影响因子：
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作者：
通讯作者：
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