Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort.
Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort.
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DOI：
10.1016/j.envint.2018.01.016
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发表时间：
2018-04
影响因子：
11.8
通讯作者：
Eskenazi B
中科院分区：
文献类型：
--
作者：
Coker E;Chevrier J;Rauch S;Bradman A;Obida M;Crause M;Bornman R;Eskenazi B
在使用拟除虫菊酯和二氯二苯三氯乙烷（DDT）进行室内滞留喷洒（IRS）控制疟疾的地区，孕妇可能会同时接触多种杀虫剂。尽管有可能对后代产生不利影响，但在目前使用IRS的地区进行的研究很少，关于拟除虫菊酯对儿童健康的影响也知之甚少。我们研究了参与前瞻性南非VHEMBE出生队列（N=708）的≤2岁儿童中尿液中四种拟除虫菊酯代谢物浓度与分娩前采集的母体血液中有机氯农药浓度之间的关系。我们使用在1岁和2岁时收集的身高/身高和体重测量值来计算体重指数（BMI）-基于世界卫生组织标准的年龄，年龄体重和身高体重z分数。我们为每个感兴趣的暴露量拟合单独的单污染物混合效应模型，并按性别分层。我们还通过使用贝叶斯核机器回归（BKMR）统计方法联合拟合所有分析物浓度，以评估每种分析物的变量重要性，并探索多次暴露联合效应的可能性。单污染物线性混合效应模型显示，仅在女孩中，p，p′-DDT与较高的年龄BMI相关（校正的[a]β=0.22 [95%CI：0.10，0.35];性别相互作用p值=0.001），身高体重（α β=0.22 [95%CI：0.09，0.34];性别相互作用p值=0.002）和年龄别体重（α β=0.17 [95%CI：0.05，0.29]，性别相互作用p值=0.01）。尽管单一污染物模型表明p，p '-DDT和二氯二苯二氯乙烯（p，p'-DDE）也与女孩的这些结果相关，但在多污染物模型中，p，p '-DDE不再与BKMR相关。拟除虫菊酯代谢物顺式-（2，2-二溴乙烯基）-2，2-二甲基环丙烷-1-羧酸（顺式-DBCA）和反式-3-（2，2-二氯乙烯基）-2，2-二甲基环丙烷羧酸（trans-DCCA）与年龄BMI和身高体重呈负相关;然而，结果表明，trans-DCCA的年龄体重和身高体重相关性（性别交互作用p值年龄别体重=0.02; p值身高别体重=0.13）和顺式DCCA（性别交互作用p值年龄别体重=0.02; p值身高别体重=0.08）在男孩中相对于女孩最强且最一致。BKMR还揭示了化学混合物的联合效应。例如，随着p，p′-DDE浓度的增加，顺式DBCA对年龄BMI的负向反应关系变得更陡峭。我们的单污染物和多污染物模型结果表明，母体血清p，p′-DDT浓度与年轻女孩的身体组成和体重一致且呈正相关，母体尿拟除虫菊酯代谢物浓度（特别是顺式-DBCA和反式-DCCA）与年轻男孩的体重和身体组成呈负相关。杀虫剂接触混合物的联合效应也很明显，这突出表明了使用先进的统计方法来审查化学混合物对健康影响的重要性。
Pregnant women may be co-exposed to multiple insecticides in regions where both pyrethroids and dichlorodiphenyltrichloroethane (DDT) are used for indoor residual spraying (IRS) for malaria control. Despite the potential for adverse effects on offspring, there are few studies in areas where IRS is currently used and little is known about the effects of pyrethroids on children’s health. We investigated the relationship between concentrations of four urinary pyrethroid metabolites in urine and organochlorine pesticide concentrations in maternal blood collected near delivery on body weight and body composition among children ≤2 years old participating in the prospective South Africa VHEMBE birth cohort (N=708). We used measurements of length/height and weight collected at 1 and 2 years of age to calculate body mass index (BMI)-for-age, weight-for-age, and weight-for-height z-scores based on World Health Organization standards. We fit separate single-pollutant mixed effects models for each exposure of interest and also stratified by sex. We also fit all analyte concentrations jointly by using a Bayesian kernel machine regression (BKMR) statistical method to assess variable importance of each analyte and to explore the potential for joint effects of the multiple exposures. Single-pollutant linear mixed effects models showed that, among girls only, p,p′-DDT was associated with higher BMI-for-age (adjusted [a]β=0.22 [95%CI: 0.10, 0.35]; sex interaction p-value=0.001), weight-for-height (aβ=0.22 [95%CI: 0.09, 0.34]; sex interaction p-value=0.002), and weight-for-age (aβ=0.17 [95%CI: 0.05, 0.29], sex interaction p-value=0.01). Although single-pollutant models suggested that p,p′-DDT and dichlorodiphenyldichloroethylene (p,p′-DDE) was also associated with these outcomes in girls, p,p′-DDE was no longer associated in multi-pollutant models with BKMR. The pyrethroid metabolites cis-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-1-carboxylicacid (cis-DBCA) and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA) were inversely related to BMI-for-age and weight-for-height overall; however, results suggested that weight-for-age and weight-for-height associations for trans-DCCA (sex interaction p-valueweight-for-age=0.02; p-valueweight-for-height=0.13) and cis-DCCA (sex interaction p-valueweight-for-age=0.02; p-valueweight-for-height=0.08) were strongest and most consistent in boys relative to girls. BKMR also revealed joint effects from the chemical mixture. For instance, with increased concentrations of p,p′-DDE, the negative exposure-response relationship for cis-DBCA on BMI-for-age became steeper. Our single-pollutant and multi-pollutant model results show that maternal serum p,p′-DDT concentration was consistently and positively associated with body composition and body weight in young girls and that maternal urinary pyrethroid metabolite concentrations (particularly cis-DBCA and trans-DCCA) were negatively associated with body weight and body composition in young boys. Joint effects of the insecticide exposure mixture were also apparent, underscoring the importance of using advanced statistical methods to examine the health effects of chemical mixtures.
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产前滴滴涕暴露与青春期男性的人体测量和青春期测量相关。
影响因子：
10.4
作者：
Gladen, BC;Klebanoff, MA;Hediger, ML;Katz, SH;Barr, DB;Davis, MD;Longnecker, MP
通讯作者：
Longnecker, MP
影响因子：
10.4
作者：
Cupul-Uicab LA;Klebanoff MA;Brock JW;Longnecker MP
通讯作者：
Longnecker MP
影响因子：
10.4
作者：
Cano-Sancho G;Salmon AG;La Merrill MA
通讯作者：
La Merrill MA
影响因子：
8.9
作者：
Bouwman, H.;Sereda, B.;Meinhardt, H. M.
通讯作者：
Meinhardt, H. M.
在报告基因测定中评估拟除虫菊酯杀虫剂及其代谢物的激素受体活性
影响因子：
3.8
作者：
Du, Guizhen;Shen, Ouxi;Wang, Xinru
通讯作者：
Wang, Xinru