COVID-19 Lockdown Increased the Risk of Preterm Birth.
COVID-19 Lockdown Increased the Risk of Preterm Birth.
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DOI：
10.3389/fmed.2021.705943
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发表时间：
2021
影响因子：
3.9
通讯作者：
Wu YT
中科院分区：
文献类型：
--
作者：
Lin TT;Zhang C;Chen L;Jin L;Lin XH;Pan JX;Dennis CL;Mol BW;Huang HF;Wu YT
目的：评估上海因COVID-19疫情而实施的城市封锁是否影响未受感染孕妇在不同孕期的早产率。研究方法：这项基于人群的回顾性队列研究在中国上海的国际和平妇幼保健院（IPMCH）进行。非COVID-19孕妇在封锁期间（2020年1月24日至2020年3月24日）和非封锁期间（2019年1月24日至2019年3月24日）接受围产期保健，并在IPMCH分娩活产婴儿。采用1：1倾向评分匹配和治疗权重的逆概率来评估两组之间的早产（<37周）、极早产（<34周）、早产伴胎膜早破（PROM-PTB）、自发性胎膜早破（S-PTB）和药物诱导的早产（MI-PTB）。结果：8，270名孕妇属于封锁组，9，815名孕妇属于非封锁组。封锁期间妊娠中期的孕妇比非封锁期间的孕妇有更高的PTB风险[OR：1.43（CI 1.01-2.02），ARD：1.7%（CI 0.04-3.4%），p = 0.045]。此外，与非封锁期相比，封锁期妊娠晚期孕妇的PROM-PTB风险更高[OR：1.64（CI 1.09-2.47），ARD：0.9%（CI 0.2-1.6%），p = 0.02];未发现与VPTB、S-PTB或MI-PTB发生率相关的组间差异。结论：在中国的这项队列研究中，我们发现，在COVID-19封锁期间，处于妊娠中期的未感染妇女早产的风险增加。
Purpose: To estimate whether the city-specific lockdown in Shanghai induced by the COVID-19 pandemic affected preterm birth rates among uninfected pregnant women in different trimesters. Methods: The population-based retrospective cohort study was conducted in the International Peace Maternity and Child Health Hospital (IPMCH) in Shanghai, China. Pregnant women without COVID-19 received perinatal healthcare during lockdown (from January 24, 2020 to March 24, 2020) and non-lockdown (from January 24, 2019 to March 24, 2019) period and giving birth to a live infant at IPMCH were enrolled. 1:1 propensity score matching and Inverse probability of treatment weighting were used to evaluate preterm birth (<37 weeks), very preterm birth (<34 weeks), preterm birth with premature rupture of membranes (PROM-PTB), spontaneous preterm birth with intact membranes (S-PTB), and medically induced preterm birth (MI-PTB) between two groups. Results: 8,270 pregnant women were in the lockdown group, and 9,815 were in the non-lockdown group. Pregnant women in second trimester during lockdown had a higher risk of PTB than those during the non-lockdown period [OR: 1.43 (CI 1.01–2.02), ARD: 1.7% (CI 0.04–3.4%), p = 0.045]. Furthermore, pregnant women in third trimester during lockdown had a higher risk of PROM-PTB than those during the non-lockdown period [OR: 1.64 (CI 1.09–2.47), ARD: 0.9% (CI 0.2–1.6%), p = 0.02]; no group differences were found related to rates of VPTB, S-PTB or MI-PTB. Conclusion: In this cohort study in China, we found that there was an increased risk in preterm birth for non-infected women in COVID-19 lockdown who were in their second trimester.
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影响因子：
8.1
作者：
Philip RK;Purtill H;Reidy E;Daly M;Imcha M;McGrath D;O'Connell NH;Dunne CP
通讯作者：
Dunne CP
影响因子：
168.9
作者：
Chen, Huijun;Guo, Juanjuan;Zhang, Yuanzhen
通讯作者：
Zhang, Yuanzhen
影响因子：
9.8
作者：
Wu, Yanting;Zhang, Chen;Huang, He-feng
通讯作者：
Huang, He-feng
影响因子：
3.3
作者：
Mancuso, RA;Schetter, CD;Hobel, CJ
通讯作者：
Hobel, CJ
影响因子：
7.2
作者：
Huntley, Benjamin J. F.;Mulder, Isabelle A.;Chauhan, Suneet P.
通讯作者：
Chauhan, Suneet P.