Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods.
Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods.
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随机对照试验评估了渐进式运动对代谢综合征在乳腺癌幸存者中的影响：基本原理，设计和方法。
DOI：
10.1186/1471-2407-14-238
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发表时间：
2014-04-03
期刊：
影响因子：
3.8
通讯作者：
Bernstein L
中科院分区：
文献类型：
--
作者：
Dieli-Conwright CM;Mortimer JE;Schroeder ET;Courneya K;Demark-Wahnefried W;Buchanan TA;Tripathy D;Bernstein L
代谢综合征（MetS）越来越多地出现在乳腺癌幸存者中，可能因癌症相关治疗（如化疗）而恶化。MetS极大地增加了心血管疾病和糖尿病的风险，这些疾病可能损害生存体验，并可能导致癌症复发。运动已被证明对生活质量（QOL）、身体功能、肌肉力量和耐力有积极影响，减少疲劳，改善情绪健康;然而，对代谢综合征组分（内脏肥胖、高血糖、低血清高密度脂蛋白胆固醇、高脂蛋白血症和高血压）的影响在很大程度上仍然未知。在这项试验中，我们的目标是评估综合（有氧和阻力）运动对MetS的组成部分，以及对身体健康和生活质量的影响，在乳腺癌幸存者完成癌症相关治疗后不久。本研究是一项前瞻性随机对照试验（RCT），旨在调查100名乳腺癌幸存者接受为期16周的监督渐进式有氧和阻力运动训练干预对MetS的影响。主要入选标准是组织学证实的乳腺癌I-III期，在研究开始前6个月内完成化疗和/或放疗，久坐，无肌肉骨骼疾病。主要终点为MetS;次要终点包括：肌肉力量、肩功能、心肺功能、身体成分、骨密度和生活质量。被随机分配到运动组的参与者参加3次有监督的每周运动，持续16周。随机分配到对照组的参与者在16周的观察期后接受相同的干预。这是为数不多的研究运动对乳腺癌幸存者MetS影响的RCT之一。研究结果将有助于更好地了解阻力和有氧运动训练的代谢疾病相关影响，并为干预计划提供信息，这些干预计划将在癌症生存期间最佳地改善生理和心理健康，并最终旨在改善预后。NCT 01140282;注册日期：2010年6月10日
Metabolic syndrome (MetS) is increasingly present in breast cancer survivors, possibly worsened by cancer-related treatments, such as chemotherapy. MetS greatly increases risk of cardiovascular disease and diabetes, co-morbidities that could impair the survivorship experience, and possibly lead to cancer recurrence. Exercise has been shown to positively influence quality of life (QOL), physical function, muscular strength and endurance, reduce fatigue, and improve emotional well-being; however, the impact on MetS components (visceral adiposity, hyperglycemia, low serum high-density lipoprotein cholesterol, hypertriglyceridemia, and hypertension) remains largely unknown. In this trial, we aim to assess the effects of combined (aerobic and resistance) exercise on components of MetS, as well as on physical fitness and QOL, in breast cancer survivors soon after completing cancer-related treatments. This study is a prospective randomized controlled trial (RCT) investigating the effects of a 16-week supervised progressive aerobic and resistance exercise training intervention on MetS in 100 breast cancer survivors. Main inclusion criteria are histologically-confirmed breast cancer stage I-III, completion of chemotherapy and/or radiation within 6 months prior to initiation of the study, sedentary, and free from musculoskeletal disorders. The primary endpoint is MetS; secondary endpoints include: muscle strength, shoulder function, cardiorespiratory fitness, body composition, bone mineral density, and QOL. Participants randomized to the Exercise group participate in 3 supervised weekly exercise sessions for 16 weeks. Participants randomized to the Control group are offered the same intervention after the 16-week period of observation. This is the one of few RCTs examining the effects of exercise on MetS in breast cancer survivors. Results will contribute a better understanding of metabolic disease-related effects of resistance and aerobic exercise training and inform intervention programs that will optimally improve physiological and psychosocial health during cancer survivorship, and that are ultimately aimed at improving prognosis. NCT01140282; Registration: June 10, 2010
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影响因子：
2.3
作者：
Bao, Ping-Ping;Zheng, Ying;Nechuta, Sarah;Gu, Kai;Cai, Hui;Peng, Peng;Shu, Xiao-Ou;Lu, Wei
通讯作者：
Lu, Wei
DOI：
10.1016/j.ejon.2004.03.007
发表时间：
2005-03-01
期刊：
European journal of oncology nursing : the official journal of European Oncology Nursing Society
影响因子：
--
作者：
Campbell, Anna;Mutrie, Nanette;Kearney, Nora
通讯作者：
Kearney, Nora
DOI：
10.1161/atvbaha.107.151092
发表时间：
2008-04-01
影响因子：
8.7
作者：
Grundy, Scott M.
通讯作者：
Grundy, Scott M.
影响因子：
3.1
作者：
De Backer, Ingrid C.;Van Breda, Eric;Schep, Goof
通讯作者：
Schep, Goof
影响因子：
--
作者：
Burgess, C;Cornelius, V;Ramirez, A
通讯作者：
Ramirez, A