Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs in human serum from Shanghai, China: a study on their presence and correlations
Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs in human serum from Shanghai, China: a study on their presence and correlations
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中国上海人血清中的多溴二苯醚 (PBDE) 和羟基化 PBDE：其存在及其相关性研究
DOI：
10.1007/s11356-017-0709-4
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发表时间：
2018-02
影响因子：
5.8
通讯作者：
Xu G
中科院分区：
文献类型：
--
作者：
Xu Bentuo;Wu Minghong;Pan Chenyuan;Tang Liang;Xu Gang;Wang Mingnan;Qiu Wenhui;Xu G
多溴联苯醚（PBDEs）由于其潜在的毒性，从内分泌干扰系统到神经发育障碍，正成为一个公共卫生问题。然而，关于它们在人体血液中的含量的信息很少。本研究在中国上海采集了人血清样本，分析了多溴二苯醚及其羟基代谢物（OH-PBDEs）的浓度。采用气相色谱-质谱联用（GC-MS）和高效液相色谱-串联质谱联用（HPLC-MS/MS）对血清样品中8种PBDE同系物和6种OH-PBDE同系物进行定量分析。结果，总PBDE浓度范围为0.280至12.330 ng g - 1（中位数：1.100 ng g - 1lw），总OH-PBDE水平范围为0.045至0.363 ng g - 1（中位数：0.187 ng g - 1lw）。其中，BDE-47和6-OH-BDE-47分别是主要的PBDEs和OH-PBDEs。此外，BartelettX2test结果显示，BDE-47与BDE-28、BDE-100、BDE-85、BDE-154的相关性显著（p< 0.05），而3′-OH-BDE-7与3′- oh -BDE-47、2′- oh - bde -68、6′-OH-BDE-99的相关性显著（p< 0.01）。在所有供体中，年龄与多溴二苯醚（或oh -多溴二苯醚）之间没有显著关联。多溴二苯醚在环境中的暴露途径及在人体血液中的代谢过程的进一步研究是必要的。
Polybrominated diphenyl ethers (PBDEs) are becoming a public health concern because of their potential toxicity, from endocrine disruption system to neurodevelopmental impairments. Nonetheless, information on their levels in human blood is scarce. In this study, human serum samples collected in Shanghai, China, were analyzed for the concentrations of PBDEs and their hydroxylated metabolites (OH-PBDEs). Eight PBDE congeners and six OH-PBDE congeners were quantified in serum samples by gas chromatography with mass spectrometry (GC-MS) and high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). As a result, total PBDE concentration ranged from 0.280 to 12.330 ng g−1on a lipid weight basis lw (median: 1.100 ng g−1lw) and the total OH-PBDE level ranged from 0.045 to 0.363 ng g−1(lw) (median: 0.187 ng g−1lw). Among them, BDE-47 and 6-OH-BDE-47 were the predominant PBDEs and OH-PBDEs, respectively. In addition, based on the results of the BartelettX2test, BDE-47 significantly (p< 0.05) correlated with BDE-28, BDE-100, BDE-85, and BDE-154, whereas 3′-OH-BDE-7 significantly (p< 0.01) correlated with 3-OH-BDE-47, 2-OH-BDE-68, and 6′-OH-BDE-99. Among all donors, no significant association between age and PBDEs (or OH-PBDEs) was found. Further research on the exposure routes in the environment and metabolic processing of PBDEs in human blood is necessary.
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影响因子：
8.8
作者：
Yufeng Jiang;Xuetong Wang;K. Zhu;Ming-hong Wu;G. Sheng;Jia-mo Fu
通讯作者：
Yufeng Jiang;Xuetong Wang;K. Zhu;Ming-hong Wu;G. Sheng;Jia-mo Fu
影响因子：
6.8
作者：
Chunyan Wang;Zeng Lin;Q. Dong;Zhenkun Lin;Kuangfei Lin;Junxia Wang;Jianxiong Huang;Xuehui Huang;Yini He;Chenping Huang;Dongren Yang;Changjiang Huang
通讯作者：
Chunyan Wang;Zeng Lin;Q. Dong;Zhenkun Lin;Kuangfei Lin;Junxia Wang;Jianxiong Huang;Xuehui Huang;Yini He;Chenping Huang;Dongren Yang;Changjiang Huang
影响因子：
4.1
作者：
Chu, Shaogang;Letcher, Robert J.
通讯作者：
Letcher, Robert J.
DOI：
10.1016/j.scitotenv.2015.07.025
发表时间：
2015-12
期刊：
The Science of the total environment
影响因子：
--
作者：
Peiwei Xu;Xiao-ming Lou;Gang-qiang Ding;Haitao Shen;Lizhi Wu;Zhijian Chen;Jian-long Han;Xiaofeng Wang
通讯作者：
Peiwei Xu;Xiao-ming Lou;Gang-qiang Ding;Haitao Shen;Lizhi Wu;Zhijian Chen;Jian-long Han;Xiaofeng Wang
影响因子：
4.1
作者：
M. Houde;G. Pacepavicius;C. Darling;P. Fair;M. Alaee;G. Bossart;K. Solomon;R. Letcher;A. Bergman;G. Marsh;D. Muir
通讯作者：
M. Houde;G. Pacepavicius;C. Darling;P. Fair;M. Alaee;G. Bossart;K. Solomon;R. Letcher;A. Bergman;G. Marsh;D. Muir