Environmental chemicals in pregnant women in the United States: NHANES 2003-2004.
Environmental chemicals in pregnant women in the United States: NHANES 2003-2004.
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DOI：
10.1289/ehp.1002727
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发表时间：
2011-06
影响因子：
10.4
通讯作者：
Schwartz JM
中科院分区：
文献类型：
--
作者：
Woodruff TJ;Zota AR;Schwartz JM
在胎儿发育期间接触化学品会增加对健康产生不良影响的风险，虽然生物监测研究表明孕妇接触化学品，但对美国孕妇接触多种化学品的程度知之甚少。我们分析了来自国家健康和营养检查调查（NHANES）的生物监测数据，以描述美国孕妇的个体和多种化学品暴露。我们分析了来自NHANES 2003-2004年的268名孕妇的12个化学类别中163种化学分析物的数据，NHANES是美国人口的全国代表性样本。对于每种化学分析物，我们计算了描述性统计量。我们计算了在以下化学类别中检测到的化学品数量：多溴联苯醚（PBDEs），全氟化合物（PFCs），有机氯农药和邻苯二甲酸酯以及多个化学类别。我们使用最小二乘几何平均值比较了孕妇和非孕妇的化学分析物浓度，调整了人口统计学和生理学协变量。可检测到某种化学物质水平的孕妇百分比从0到100%不等。在99-100%的孕妇体内检测到某些多氯联苯、有机氯农药、全氟碳化物、苯酚、多溴二苯醚、邻苯二甲酸盐、多环芳烃和高氯酸盐。按化学类别划分，检测到的化学品的中位数从12种全氟化学品中的4种到13种邻苯二甲酸酯中的9种不等。在化学类别中，中位数范围从17种化学分析物中的8种到71种化学分析物中的50种。我们发现，一般来说，孕妇的水平与非孕妇的水平相似或低于非孕妇的水平;与非孕妇相比，对协变量的调整往往会增加孕妇的水平。美国孕妇暴露于多种化学物质。有必要进一步努力了解风险来源和对决策的影响。
Exposure to chemicals during fetal development can increase the risk of adverse health effects, and while biomonitoring studies suggest pregnant women are exposed to chemicals, little is known about the extent of multiple chemicals exposures among pregnant women in the United States. We analyzed biomonitoring data from the National Health and Nutritional Examination Survey (NHANES) to characterize both individual and multiple chemical exposures in U.S. pregnant women. We analyzed data for 163 chemical analytes in 12 chemical classes for subsamples of 268 pregnant women from NHANES 2003–2004, a nationally representative sample of the U.S. population. For each chemical analyte, we calculated descriptive statistics. We calculated the number of chemicals detected within the following chemical classes: polybrominated diphenyl ethers (PBDEs), perfluorinated compounds (PFCs), organochlorine pesticides, and phthalates and across multiple chemical classes. We compared chemical analyte concentrations for pregnant and nonpregnant women using least-squares geometric means, adjusting for demographic and physiological covariates. The percentage of pregnant women with detectable levels of an individual chemical ranged from 0 to 100%. Certain polychlorinated biphenyls, organochlorine pesticides, PFCs, phenols, PBDEs, phthalates, polycyclic aromatic hydrocarbons, and perchlorate were detected in 99–100% of pregnant women. The median number of detected chemicals by chemical class ranged from 4 of 12 PFCs to 9 of 13 phthalates. Across chemical classes, median number ranged from 8 of 17 chemical analytes to 50 of 71 chemical analytes. We found, generally, that levels in pregnant women were similar to or lower than levels in nonpregnant women; adjustment for covariates tended to increase levels in pregnant women compared with nonpregnant women. Pregnant women in the U.S. are exposed to multiple chemicals. Further efforts are warranted to understand sources of exposure and implications for policy making.
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影响因子：
10.4
作者：
Herbstman JB;Sjödin A;Kurzon M;Lederman SA;Jones RS;Rauh V;Needham LL;Tang D;Niedzwiecki M;Wang RY;Perera F
通讯作者：
Perera F
DOI：
10.3109/00365516809076969
发表时间：
1968-01-01
影响因子：
2.1
作者：
HONGER, PE
通讯作者：
HONGER, PE
DOI：
10.1038/jes.2008.32
发表时间：
2009-01-01
影响因子：
4.5
作者：
Caldwell, Kathleen L.;Jones, Robert L.;Osterloh, John D.
通讯作者：
Osterloh, John D.
DOI：
10.1111/j.1742-7843.2009.00455.x
发表时间：
2009-11-01
影响因子：
3.1
作者：
Allmyr, Mats;Panagiotidis, Georgios;Sandborgh-Englund, Gunilla
通讯作者：
Sandborgh-Englund, Gunilla
影响因子：
--
作者：
Crofton, Kevin M.
通讯作者：
Crofton, Kevin M.