Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography.
Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography.
复制标题
通过扫描源光学相干断层扫描血管造影检测青光眼中的视盘微血管缺失。
DOI：
10.1016/j.ajo.2021.10.029
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发表时间：
2022-04
影响因子：
4.2
通讯作者：
Zangwill LM
中科院分区：
文献类型：
--
作者：
Suh MH;Jung DH;Weinreb RN;Zangwill LM
目的评价扫频光源光学相干断层扫描血管造影（SS-OCTA）检测原发性开角型青光眼（POAG）视盘微血管脱落（MvD-D）的临床应用价值。横断面研究。入选了197例POAG患者的197只眼，其SS-OCTA（PLEX Elite 9000; Carl Zeiss Meditec，都柏林，CA，USA）图像质量可接受。去除投影伪影后得到全信号模式的6.0×6.0 mm视盘立方体。分为三组：无MvD-D（第1组）、MvD-D（第2组，视盘内微血管完全丧失）和不可辨别的MvD-D（第3组，前筛板（LC）可视化差）。分别有82只眼（42.1%）和81只眼（41.5%）被归类为无MvD-D（组1）和MvD-D（组2）。其余32只眼（16.4%），归类为不可辨别的MvD-D（组3），具有显著较小的前巩膜管开口（ASCO）面积（P < 0.05）。第2组的视野平均偏差（MD）、平均视网膜神经纤维层（RNFL）、局灶性LC缺损和乳头旁深层微血管脱落（MvD-P）均明显低于其他两组（P < 0.05）。在多因素Logistic回归分析中，局灶性LC缺损（OR，46.91; P <0.001）和MvD-P（OR，48.94; P <0.001）的患病率较高仍然是MvD-D的相关因素。SS OCTA能较好地检测POAG眼内MvD-D的存在。MvD-P和局灶性LC缺陷与MvD-D密切相关。这表明SS-OCTA可以作为检测视盘微血管损伤的有用工具。在83.6%的原发性开角型青光眼受试者中，通过扫频源光学相干断层扫描血管造影可评估视盘微血管脱落（MvD-D）。局灶性筛板缺损和乳头旁深层微血管脱落与MvD-D密切相关。
To assess the clinical utility of swept-source optical coherence tomography angiography (SS-OCTA) in detecting optic disc microvasculature dropout (MvD-D) in primary open-angle glaucoma (POAG) eyes. Cross sectional study. One hundred and ninety-seven eyes of 197 POAG patients with acceptable-quality SS-OCTA (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA, USA) images were enrolled. A whole-signal-mode 6.0×6.0-mm optic disc cube was obtained with projection artifact removal. Three groups were categorized: no MvD-D (Group 1), MvD-D (Group 2, complete loss of microvasculature within the optic disc), and indiscernible MvD-D (Group 3, poor visualization of the anterior lamina cribrosa (LC)). Eighty-two (42.1%) and 81 (41.5%) eyes were categorized as no MvD-D (Group 1) and MvD-D (Group 2), respectively. The remaining 32 eyes (16.4%), categorized as indiscernible MvD-D (Group 3), had a significantly smaller anterior scleral canal opening (ASCO) area (P < 0.05). Group 2 had significantly worse visual field (VF) mean deviation (MD), thinner average retinal nerve fiber layer (RNFL), higher prevalence of focal LC defect, and parapapillary deep-layer microvasculature dropout (MvD-P) than the other two groups (P < 0.05). In the multivariable logistic regression analysis, higher prevalence of focal LC defect (odds ratio (OR), 46.91; P <0.001) and MvD-P (OR, 48.94; P <0.001) remained as factors associated with MvD-D. The presence of MvD-D could be well determined by SS-OCTA in POAG eyes. MvD-P and focal LC defects were strongly associated with MvD-D. This suggests that SS-OCTA can serve as a useful tool in detecting optic disc microvasculature damage. Optic disc microvasculature dropout (MvD-D) was assessable by swept-source optical coherence tomography angiography in 83.6% of primary open-angle glaucoma subjects. Focal lamina cribrosa defect and parapapillary deep-layer microvasculature dropout were strongly associated with MvD-D.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
4.1
作者：
Kim, Ji-Ah;Kim, Tae-Woo;Mari, Jean Martial
通讯作者：
Mari, Jean Martial
影响因子：
4.2
作者：
Kwon, Ji Min;Weinreb, Robert N.;Suh, Min Hee
通讯作者：
Suh, Min Hee
影响因子：
13.7
作者：
Lopilly, Hae-Young;Kim, Jin Woo;Park, Chan Kee
通讯作者：
Park, Chan Kee
DOI：
10.1097/iae.0000000000003109
发表时间：
2021-07-01
影响因子：
3.3
作者：
Ledesma-Gil, Gerardo;Fernandez-Avellaneda, Pedro;Spaide, Richard F.
通讯作者：
Spaide, Richard F.