Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors.
Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors.
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DOI：
10.1016/j.mce.2013.07.024
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发表时间：
2013-12-05
影响因子：
4.1
通讯作者：
Marsit CJ
中科院分区：
文献类型：
--
作者：
Lesseur C;Armstrong DA;Paquette AG;Koestler DC;Padbury JF;Marsit CJ
瘦素是一种体重调节剂，参与生殖和发育功能。瘦素启动子DNA甲基化(LEP)以组织特异性的方式调节基因表达，并与不良妊娠结局有关。在非病理性人类妊娠中，我们评估了LEP甲基化，对胎盘(n=81)、母亲和脐带血样本(n=60)的单核苷酸多态(SNP)rs2167270进行了基因分型，并检查了甲基化、基因和围产期因素之间的关系。孕前肥胖妇女母血LEP甲基化水平较低(P=0.01)。孕前肥胖母亲所生新生儿脐血低密度脂蛋白甲基化水平较高(P=4.6×10−3)和A/A基因型(P=1.6×10−4)，低甲基化水平(−1.47，P=0.0 3)，且与母血低密度脂蛋白水平相关(P=0.0 1)。性别与胎盘LEP甲基化有关(P=0.05)。这些结果表明，LEP的表观遗传控制可能受到围产期因素的影响，包括：母亲肥胖、婴儿生长、基因和性别以组织特异性的方式，并可能具有多代影响。
Leptin a regulator of body weight is involved in reproductive and developmental functions. Leptin promoter DNA methylation (LEP) regulates gene expression in a tissue-specific manner and has been linked to adverse pregnancy outcomes. In non-pathologic human pregnancies, we assessed LEP methylation, genotyped the single nucleotide polymorphism (SNP) rs2167270 in placental (n=81), maternal and cord blood samples (n=60), and examined the association between methylation, genotype, and perinatal factors. Maternal blood LEP methylation was lower in pre-pregnancy obese women (P=0.01). Cord blood LEP methylation was higher in small for gestational age (SGA) (P=4.6×10−3) and A/A genotype (P=1.6×10−4), lower (−1.47, P=0.03) in infants born to pre-pregnancy obese mothers and correlated (P=0.01) with maternal blood LEP. Gender was associated with placental LEP methylation (P=0.05). These results suggest that LEP epigenetic control may be influenced by perinatal factors including: maternal obesity, infant growth, genotype and gender in a tissue-specific manner and may have multigenerational implications.
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影响因子：
2.4
作者：
Fenton TR;Kim JH
通讯作者：
Kim JH
影响因子：
3.7
作者：
Marsit CJ;Maccani MA;Padbury JF;Lester BM
通讯作者：
Lester BM
影响因子：
82.9
作者：
Masuzaki, H;Ogawa, Y;Nakao, K
通讯作者：
Nakao, K
影响因子：
7.7
作者：
Martínez-Cordero, C;Amador-Licona, N;Ruelas-Orozco, G
通讯作者：
Ruelas-Orozco, G
DOI：
10.1530/ror.0.0050018
发表时间：
2000-01-01
期刊：
REVIEWS OF REPRODUCTION
影响因子：
--
作者：
Ashworth, CJ;Hoggard, N;Lea, RG
通讯作者：
Lea, RG