Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium.
Three new compounds from Aspergillus terreus PT06-2 grown in a high salt medium.
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来自高盐培养基中生长的土曲霉 PT06-2 的三种新化合物
作者：
Wang Y;Zheng J;Liu P;Wang W;Zhu W
为了研究高盐度下来自海洋微生物的结构新颖且具有生物活性的天然化合物，从中国福建莆田海盐场的沉积物中分离出了真菌土曲霉 PT06-2。从盐度为 10% 的 A. terreus PT06-2 发酵液中分离并鉴定出三种新化合物，terremides A (1) 和 B (2) 以及 terrelactone A (3)，以及十二种已知化合物 (4-15)。在这些代谢物中，化合物4和15仅在10%盐度培养物中产生，分别被鉴定为3,4,5-三甲氧基-2-(2-(烟酰胺基)苯甲酰胺基)苯甲酸甲酯和(+)-土曲霉。新化合物1和2对铜绿假单胞菌和产气肠杆菌具有抗菌活性，MIC值分别为63.9和33.5 μM。化合物5表现出中等的抗H1N1流感活性和较低的细胞毒性，IC50和CC50值分别为143.1和976.4μM。
To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4–15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 μM, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC50 and CC50 values of and 143.1 and 976.4 μM, respectively.
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影响因子：
7.6
作者：
Hung HC;Tseng CP;Yang JM;Ju YW;Tseng SN;Chen YF;Chao YS;Hsieh HP;Shih SR;Hsu JT
通讯作者：
Hsu JT
DOI：
10.1073/pnas.77.7.3957
发表时间：
1980-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ALBERTS, AW;CHEN, J;SPRINGER, J
通讯作者：
SPRINGER, J
影响因子：
2.1
作者：
Heredia, ML;de la Cuesta, E;Avenda単o, C
通讯作者：
Avenda単o, C
影响因子：
4.8
作者：
Grassauer A;Weinmuellner R;Meier C;Pretsch A;Prieschl-Grassauer E;Unger H
通讯作者：
Unger H
异紫萼苷型生物碱，variecolorins A-L，来自耐盐曲霉
影响因子：
5.1
作者：
Wang, Wen-Liang;Lu, Zhen-Yu;Zhu, Wei-Ming
通讯作者：
Zhu, Wei-Ming