Timing of plant immune responses by a central circadian regulator.
Timing of plant immune responses by a central circadian regulator.
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DOI：
10.1038/nature09766
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发表时间：
2011-02-03
期刊：
影响因子：
64.8
通讯作者：
Dong X
中科院分区：
文献类型：
--
作者：
Wang W;Barnaby JY;Tada Y;Li H;Tör M;Caldelari D;Lee DU;Fu XD;Dong X
植物对活体营养型病原体的主要免疫机制是抗性（R）基因介导的防御。有人提议与广泛的基础防御机制分享组成部分。然而，潜在的分子机制在很大程度上是未知的。在这里，我们报告了新的基因参与R-基因介导的抗霜霉病拟南芥和他们的昼夜节律调节器，昼夜节律时钟相关1（CCA 1）的调控控制。基于这些基因突变体表型的数值聚类显示，程序性细胞死亡（PCD）是抗性的主要贡献者。在R基因介导的PCD中受损的突变体在基础抗性中也有缺陷，从而在这两种不同的防御机制之间建立了相互联系。令人惊讶的是，我们发现这些新的防御基因受到CCA 1的昼夜节律控制，使植物能够在黎明时“预测”感染，此时病原体通常会分散孢子，并根据感染后对不同病原信号的感知来确定免疫反应的时间。防御基因的时间控制由CCA 1区分他们参与基础和R-基因介导的防御。我们的研究揭示了生物钟和植物免疫之间的关键功能联系。
The principal immune mechanism against biotrophic pathogens in plants is the resistance (R)-gene-mediated defence. It was proposed to share components with the broad-spectrum basal defence machinery. However, the underlying molecular mechanism is largely unknown. Here we report the identification of novel genes involved in R-gene-mediated resistance against downy mildew in Arabidopsis and their regulatory control by the circadian regulator, CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1). Numerical clustering based on phenotypes of these gene mutants revealed that programmed cell death (PCD) is the major contributor to resistance. Mutants compromised in the R-gene-mediated PCD were also defective in basal resistance, establishing an interconnection between these two distinct defence mechanisms. Surprisingly, we found that these new defence genes are under circadian control by CCA1, allowing plants to ‘anticipate’ infection at dawn when the pathogen normally disperses the spores and time immune responses according to the perception of different pathogenic signals upon infection. Temporal control of the defence genes by CCA1 differentiates their involvement in basal and R-gene-mediated defence. Our study has revealed a key functional link between the circadian clock and plant immunity.
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