Irreversible, Self-Aligned Microfluidic Packaging for Chronic Implant Applications.
Irreversible, Self-Aligned Microfluidic Packaging for Chronic Implant Applications.
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用于慢性植入应用的不可逆自对准微流体包装。
DOI：
10.1088/1361-6439/ac1994
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发表时间：
2021-09
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影响因子：
--
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中科院分区：
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--
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在生物医学植入应用的微流体装置中，包装是一个经常被忽视的组成部分。坚固可靠的连接器连接微观尺度和宏观尺度的特征对于慢性植入物的应用尤为重要。现有的微流体包装方法与旨在增强设备与周围组织集成的新兴聚合物材料不兼容。开发了一种微流控连接器方案，以促进与新材料和植入应用的兼容性。连接器和粘合剂蜡通过增材制造工艺打印在支架上。低温封装过程需要使用粘合剂蜡将连接器粘合到基于聚合物纳米复合材料的皮质内微流控探针上。通过测量连接器-粘合剂蜡-聚合物薄膜界面的拉伸和剪切结合强度来评估包装的坚固性。浸泡测试4周后，粘结强度继续超过通过微流体通道注入流体所需的力。此外，剪切粘结强度超过典型的探针插入力至少10倍。这些结果支持使用连接器和热粘合方法作为慢性种植体应用的可行选择。
Packaging is an often overlooked component in microfluidic devices for biomedical implant applications. Robust and reliable connectors to interface microscale and macroscale features are especially critical for chronic implant applications. Existing microfluidic packaging methods are incompatible with emerging polymeric materials designed to enhance device integration with the surrounding tissue. A microfluidic connector scheme was developed to promote compatibility with novel materials and implant applications. The connectors and an adhesive wax were printed on a scaffold via additive manufacturing processes. The low-temperature packaging process entailed bonding the connector to a polymer nanocomposite-based intracortical microfluidic probe using an adhesive wax. The robustness of the packaging was assessed by measuring the tensile and shear bond strengths of the connector-adhesive wax-polymer film interface. After soak testing for 4 weeks, the bond strength continued to exceed the force required to infuse fluids through the microfluidic channel. Further, the shear bond strength exceeded typical probe insertion forces by at least 10-fold. These results support the use of the connector and thermal bonding method as a viable option for chronic implant applications.
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