Dexamethasone-Enhanced Microdialysis and Penetration Injury.
Dexamethasone-Enhanced Microdialysis and Penetration Injury.
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DOI：
10.3389/fbioe.2020.602266
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发表时间：
2020
影响因子：
5.7
通讯作者：
Michael AC
中科院分区：
文献类型：
--
作者：
Jaquins-Gerstl A;Michael AC
微透析探针、电化学微传感器和神经假体通常用于体内监测，但这些都是直接植入脑组织的侵入性设备。虽然这些装置的选择性、灵敏度和时间分辨率已经被详细地表征，但是较少关注它们对组织造成的创伤的影响或任何此类创伤对它们用于执行的测量结果的影响。影响脑组织对植入器械反应的因素包括：插入过程中的机械创伤、异物反应、植入方法和器械的物理特性（尺寸、形状和表面特征）。调节免疫反应是使这些设备具有可靠的长期性能的重要一步。局部释放抗炎剂如地塞米松（DEX）通常用于减轻异物反应。在这篇文章中，微透析用于局部递送DEX到周围的脑组织。这项工作讨论了微透析探针植入引起的免疫反应。我们简要回顾了微透析的原理和DEX与微透析在（i）神经元器件，（ii）多巴胺和快速扫描循环伏安法，（iii）衰减的小胶质细胞，（iv）巨噬细胞极化状态，（v）扩展去极化。本文讨论了这些应用中的困难和复杂性。
Microdialysis probes, electrochemical microsensors, and neural prosthetics are often used for in vivo monitoring, but these are invasive devices that are implanted directly into brain tissue. Although the selectivity, sensitivity, and temporal resolution of these devices have been characterized in detail, less attention has been paid to the impact of the trauma they inflict on the tissue or the effect of any such trauma on the outcome of the measurements they are used to perform. Factors affecting brain tissue reaction to the implanted devices include: the mechanical trauma during insertion, the foreign body response, implantation method, and physical properties of the device (size, shape, and surface characteristics. Modulation of the immune response is an important step toward making these devices with reliable long-term performance. Local release of anti-inflammatory agents such as dexamethasone (DEX) are often used to mitigate the foreign body response. In this article microdialysis is used to locally deliver DEX to the surrounding brain tissue. This work discusses the immune response resulting from microdialysis probe implantation. We briefly review the principles of microdialysis and the applications of DEX with microdialysis in (i) neuronal devices, (ii) dopamine and fast scan cyclic voltammetry, (iii) the attenuation of microglial cells, (iv) macrophage polarization states, and (v) spreading depolarizations. The difficulties and complexities in these applications are herein discussed.
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影响因子：
5
作者：
Bettinger CJ;Ecker M;Kozai TDY;Malliaras GG;Meng E;Voit W
通讯作者：
Voit W
影响因子：
11.2
作者：
Bosche, Bert;Graf, Rudolf;Ernestus, Ralf-Ingo;Dohmen, Christian;Reithmeier, Thomas;Brinker, Gerrit;Strong, Anthony J.;Dreier, Jens P.;Woitzik, Johannes
通讯作者：
Woitzik, Johannes
影响因子：
12.7
作者：
BENVENISTE, H;DIEMER, NH
通讯作者：
DIEMER, NH
影响因子：
3
作者：
Borland, LM;Shi, GY;Michael, AC
通讯作者：
Michael, AC
DOI：
10.1111/j.1600-0773.1991.tb01315.x
发表时间：
1991-11-01
期刊：
PHARMACOLOGY & TOXICOLOGY
影响因子：
--
作者：
CARNEHEIM, C;STAHLE, L
通讯作者：
STAHLE, L