Regulation of the cardiomyocyte population in the developing heart.
Regulation of the cardiomyocyte population in the developing heart.
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DOI：
10.1016/j.pbiomolbio.2010.11.010
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发表时间：
2011-07
影响因子：
3.8
通讯作者：
Giraud G
中科院分区：
文献类型：
--
作者：
Thornburg K;Jonker S;O'Tierney P;Chattergoon N;Louey S;Faber J;Giraud G
在胎儿期，心肌通过心肌细胞的复制而扩张。在绵羊中，心肌细胞开始在妊娠145天中的约100天开始终末分化的过程。在发育的最后一步，心肌细胞变成双核并停止分裂。出生时的细胞数量对于决定终身心肌细胞的数量非常重要。因此，子宫内心肌细胞生长的调节对长期疾病结果至关重要。刺激胎儿心肌细胞增殖的生长因子包括血管紧张素II、皮质醇和胰岛素样生长因子-1。增加的心室壁应力导致增殖的短期增加，但心肌细胞生成能力的长期丧失。两种正常循环的激素已被确定为抑制增殖：心房钠尿肽（ANP）和三碘-L-甲状腺原氨酸（T3）。心房利钠肽通过作为鸟苷酸环化酶的NPRA受体发出信号，并通过cGMP发出信号。在培养的心肌细胞中，当血管紧张素II存在时，ANP强烈抑制有丝分裂活性。添加cGMP类似物具有与ANP相同的效果。ANP抑制细胞外受体激酶和磷酸肌醇3激酶途径。T3还抑制刺激心肌细胞的有丝分裂活性增加，但通过增加细胞周期抑制剂p21和减少细胞周期激活剂细胞周期蛋白D1来实现。
During fetal life the myocardium expands through replication of cardiomyocytes. In sheep, cardiomyocytes begin the process of becoming terminally differentiated at about 100 gestation days out of 145 days term. In this final step of development, cardiomyocytes become binucleated and stop dividing. The number of cells at birth is important in determining the number of cardiomyocytes for life. Therefore, the regulation of cardiomyocyte growth in the womb is critical to long term disease outcome. Growth factors that stimulate proliferation of fetal cardiomyocytes include angiotensin II, cortisol and insulin-like growth factor-1. Increased ventricular wall stress leads to short term increases in proliferation but longer term loss of cardiomyocyte generative capacity. Two normally circulating hormones have been identified that suppress proliferation: atrial natriuretic peptide (ANP) and tri-iodo-L-thyronine (T3). Atrial natriuretic peptide signals through the NPRA receptor that serves as a guanylate cyclase and signals through cGMP. ANP powerfully suppresses mitotic activity in cardiomyocytes in the presence of angiotensin II in culture. Addition of a cGMP analogue has the same effect as ANP. ANP suppresses both the extracellular receptor kinases and the phosphoinositol 3 kinase pathways. T3 also suppresses increased mitotic activity of stimulated cardiomyocytes but does so by increasing the cell cycle suppressant, p21, and decreasing the cell cycle activator, cyclin D1.
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影响因子：
37.8
作者：
Crispi, Fatima;Bijnens, Bart;Gratacos, Eduard
通讯作者：
Gratacos, Eduard
影响因子：
9.8
作者：
Cock, ML;Albuquerque, CA;Harding, R
通讯作者：
Harding, R
DOI：
10.1152/ajpregu.2000.279.4.r1157
发表时间：
2000-10-01
影响因子：
2.8
作者：
Barbera, A;Giraud, GD;Thornburg, KL
通讯作者：
Thornburg, KL
影响因子：
--
作者：
BARKER, DJP;MARTYN, CN;FALL, CHD
通讯作者：
FALL, CHD
影响因子：
3.3
作者：
Giraud, GD;Faber, JJ;Anderson, DF
通讯作者：
Anderson, DF