Analysis of Progranulin-Mediated Akt and MAPK Activation.

Analysis of Progranulin-Mediated Akt and MAPK Activation.
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颗粒体蛋白前体介导的 Akt 和 MAPK 激活分析。

DOI:
10.1007/978-1-4939-8559-3_9
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发表时间:
2018
期刊:
Methods in molecular biology (Clifton, N.J.)
影响因子:
--
通讯作者:
Morrione,Andrea
Morrione,Andrea
中科院分区:
--
文献类型:
--
作者:
Xu,Shi-Qiong;Buraschi,Simone;Tanimoto,Ryuta;Stefanello,Manuela;Belfiore,Antonino;Iozzo,RenatoV;Morrione,Andrea

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Progranulin has emerged in recent years as an important regulator of various biological functions including cell proliferation, wound healing, motility, and protection from apoptosis. Progranulin is also critical for transformation as established in several cancer models.Progranulin biological responses elicit through the activation of the Akt and MAPK pathways, which are critical for progranulin downstream signaling.In this chapter various experimental approaches aiming at detecting progranulin-mediated Akt and MAPK activation will be discussed.
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