Cross‐sectional association of metrics derived from continuous glucose monitoring with cognitive performance in older adults with type 2 diabetes
Cross‐sectional association of metrics derived from continuous glucose monitoring with cognitive performance in older adults with type 2 diabetes
复制标题
连续血糖监测指标与 2 型糖尿病老年人认知表现的横断面关联
DOI：
10.1111/dom.14866
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sakurai Takashi
中科院分区：
文献类型：
--
作者：
Sugimoto Taiki;Tokuda Haruhiko;Miura Hisayuki;Kawashima Shuji;Ando Takafumi;Kuroda Yujiro;Matsumoto Nanae;Fujita Kosuke;Uchida Kazuaki;Kishino Yoshinobu;Sakurai Takashi
AimTo研究动态血糖监测（CGM）衍生指标和认知能力之间的关联在老年人与2型糖尿病（T2 D）。材料和方法共100例门诊T2 D患者年龄70岁或以上进行了分析。参与者接受了为期14天的CGM。作为CGM衍生指标，计算平均探头葡萄糖（SG）、葡萄糖变异系数（CV）、范围内时间（TIR; 70 - 180 mg/dl）、高于范围的时间（TAR; > 180 mg/dl）和低于范围的时间（TBR; < 70 mg/dl）。参与者接受认知测试，包括日语版的蒙特利尔认知评估（莫卡），阿尔茨海默病评估量表认知子量表的延迟单词回忆测试，数字符号替代测试，字母单词流畅性测试，连线测试（TMT）和数字广度测试（DSP）。较高的平均SG与莫卡和TMT部分B（TMT-B）的较低表现相关（P<0.05）。TAR越高，TMT-B和DSP-向后的表现越差（P< .05）。相比之下，较高的TIR与TMT-B和DSP-向后的较好功能相关（P< .05）。此外，CV和TBR与任何认知functions. ConclusionHyperglycemia指标和TIR来自CGM与认知功能，特别是与执行功能和工作记忆，在老年人与T2 D。
AimTo examine the association between continuous glucose monitoring (CGM)‐derived metrics and cognitive performance in older adults with type 2 diabetes (T2D).Materials and methodsA total of 100 outpatients with T2D aged 70 years or older were analysed. Participants underwent CGM for 14 days. As CGM‐derived metrics, mean sensor glucose (SG), glucose coefficient of variation (CV), time in range (TIR; 70‐180 mg/dl), time above range (TAR; > 180 mg/dl) and time below range (TBR; < 70 mg/dl), were calculated. Participants underwent cognitive tests, including the Japanese version of the Montreal Cognitive Assessment (MoCA‐J), a delayed word‐recall test from the Alzheimer's Disease Assessment Scale‐cognitive subscale, a digit symbol substitution test, a letter word fluency test, a trail‐making test (TMT) and digit span test (DSP).ResultsIn multiple regression analyses adjusted for confounders, a higher mean SG was associated with a lower performance in MoCA‐J and TMT part B (TMT‐B) (P< .05). A higher TAR was associated with a lower performance in TMT‐B and DSP‐backward (P< .05). By contrast, a higher TIR was associated with better function in TMT‐B and DSP‐backward (P< .05). Furthermore, CV and TBR were not associated with any cognitive function.ConclusionHyperglycaemia metrics and TIR derived from CGM are associated with cognitive functions, especially with executive function and working memory, in older adults with T2D.
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影响因子：
3.3
作者：
Fujiwara, Yoshinori;Suzuki, Hiroyuki;Shinkai, Shoji
通讯作者：
Shinkai, Shoji
影响因子：
16.2
作者：
Battelino, Tadej;Danne, Thomas;Phillip, Moshe
通讯作者：
Phillip, Moshe
DOI：
10.14740/jocmr3556w
发表时间：
2018-10
期刊：
Journal of clinical medicine research
影响因子：
--
作者：
Sakamoto M
通讯作者：
Sakamoto M
阿尔茨海默病评估量表（ADAS）。
影响因子：
--
作者：
Mohs Rc;L. Cohen
通讯作者：
L. Cohen
社区中的葡萄糖耐量状况和痴呆风险：久山研究
DOI：
10.11256/jjdi.17.n8
发表时间：
2015
期刊：
The Journal of Biological Chemistry
影响因子：
--
作者：
学 赤沢;草間 真紀子
通讯作者：
草間 真紀子