Progress of Platelet Derivatives for Cartilage Tissue Engineering.
Progress of Platelet Derivatives for Cartilage Tissue Engineering.
复制标题
软骨组织工程血小板衍生物研究进展
DOI：
10.3389/fbioe.2022.907356
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发表时间：
2022
影响因子：
5.7
通讯作者：
Qu, Wenrui
中科院分区：
文献类型：
--
作者：
Wu, Siyu;Guo, Wenlai;Li, Rui;Zhang, Xi;Qu, Wenrui
关键词：
关节软骨由于缺乏血管、神经和淋巴而具有有限的自我再生能力，这使得修复组织缺损和恢复受伤或衰老人群的运动功能成为一个巨大的挑战。血小板衍生物，如富血小板血浆，由于其自身来源和富含生长因子，已被证明是有效的，安全的，和经济的肌肉骨骼疾病。血小板衍生物与生物材料的组合在软骨组织工程中提供了机械支持和生物活性分子的局部缓释以及潜在治疗的低成本有效方法。本文首先综述了血小板衍生物及其在临床和实验治疗中的应用，然后进一步讨论了血小板衍生物的添加技术及其对支架性能的影响。介绍了以血小板衍生物为信号因子和结构成分的软骨组织工程的研究进展，并对该领域的研究前景进行了展望。总之，血小板衍生物作为一种经济有效的组织工程软骨修复强化剂具有广阔的应用前景。
Articular cartilage has limited self-regeneration ability for lacking of blood vessels, nerves, and lymph that makes it a great challenge to repair defects of the tissue and restore motor functions of the injured or aging population. Platelet derivatives, such as platelet-rich plasma, have been proved effective, safe, and economical in musculoskeletal diseases for their autologous origin and rich in growth factors. The combination of platelet derivatives with biomaterials provides both mechanical support and localized sustained release of bioactive molecules in cartilage tissue engineering and low-cost efficient approaches of potential treatment. In this review, we first provide an overview of platelet derivatives and their application in clinical and experimental therapies, and then we further discuss the techniques of the addition of platelet derivatives and their influences on scaffold properties. Advances in cartilage tissue engineering with platelet derivatives as signal factors and structural components are also introduced before prospects and concerns in this research field. In short, platelet derivatives have broad application prospects as an economical and effective enhancement for tissue engineering–based articular cartilage repair.
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影响因子：
3
作者：
Bolandi, Behzad;Imani, Rana;Fakhrzadeh, Hossein
通讯作者：
Fakhrzadeh, Hossein
影响因子：
4.8
作者：
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通讯作者：
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影响因子：
1.1
作者：
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通讯作者：
Tong PJ
影响因子：
7.4
作者：
Blair P;Flaumenhaft R
通讯作者：
Flaumenhaft R
DOI：
10.1016/j.arthro.2011.10.018
发表时间：
2012-03-01
影响因子：
4.7
作者：
Boswell, Stacie G.;Cole, Brian J.;Fortier, Lisa A.
通讯作者：
Fortier, Lisa A.