Safety of high-dose Puerariae Lobatae Radix in adolescent rats based on metabolomics.
Safety of high-dose Puerariae Lobatae Radix in adolescent rats based on metabolomics.
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基于代谢组学的大剂量葛根对青春期大鼠的安全性研究
DOI：
10.1002/fsn3.2044
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发表时间：
2021-03
影响因子：
3.9
通讯作者：
Dong H
中科院分区：
文献类型：
--
作者：
Chen L;Jiang E;Guan Y;Xu P;Shen Q;Liu Z;Zhu W;Chen L;Liu H;Dong H
葛根（PLR）是豆科植物葛根的干燥根，是保健品和药品的常见成分。虽然认为它是安全的，但一些研究报告PLR具有肝毒性和雌激素样作用。在本研究中，通过生化、组织病理学和代谢组学分析，评价了对青春期SD大鼠给予高剂量PLR水提取物30天的安全性。总体而言，低剂量组与空白对照组之间的参数值，包括器官湿重、器官系数、血常规指标、肝肾功能血清生化指标、雌二醇和睾酮水平、组织病理学参数和主要鉴别代谢产物谱均无显著差异。与空白对照组相比，高剂量组可能对肝脏有一定影响。这些影响可能是由异常的苯丙氨酸、酪氨酸和色氨酸生物合成或苯丙氨酸代谢介导的。然而，组织病理学分析未显示对照组和高剂量PLR水提取物处理组之间肝脏、肾脏、乳腺、子宫、卵巢、睾丸和附睾的差异。PLR水提物对雌雄性器官早熟无明显促进作用。总体而言，PLR水提取物对青春期SD大鼠相对安全。 野葛既可入药，又可食用。安全性高，可用于日常食用。它可用于保健食品和药品的开发，但它含有较多的植物雌激素（雌激素），可能会对青少年人群产生一定的影响。我们通过喂养青春期雄性和雌性SD大鼠来评价大剂量中药葛根用于青春期的安全性。本研究发现，麦冬水提取物对青春期SD大鼠是相对安全的。
Puerariae Lobatae Radix (PLR) is the dried root of the leguminous plant Pueraria lobata and is a common component of health products and medicines. Although it is considered safe, some studies have reported that PLR has hepatotoxicity and estrogen‐like effects. In this study, the safety of high doses of PLR water extract administered to adolescent SD rats for 30 days was evaluated by biochemical, histopathological, and metabolomic analyses. Overall, there were no significant differences between the low‐dose and blank control groups in parameter values, including organ wet weight, organ coefficient, routine blood indicators, serum biochemical indexes of liver and renal function, levels of estradiol and testosterone, histopathological parameters, and primary differential metabolite profiles. Compared with the blank control group, the high‐dose group may have a certain effect on the liver. These effects might be mediated by abnormal phenylalanine, tyrosine, and tryptophan biosynthesis or phenylalanine metabolism. However, histopathological analyses did not show differences in the liver, kidney, breast, uterus, ovary, testis, and epididymis between the control group and the group treated with a high dose of PLR water extract. PLR water extract did not significantly promote the precocity of male and female sexual organs. Overall, PLR water extract is relatively safe for adolescent SD rats. Pueraria lobata can be used as a medicine and as a food. It has high safety and can be used for daily consumption. It can be used in the development of health food and medicine, but it contains more phytoestrogens (isoflavones) which may have a certain impact on the adolescent population. We evaluated the safety of large‐dose Chinese medicine Pueraria lobata for puberty by feeding adolescent male and female SD rats. This research found that Puerariae Lobatae Radix water extract was relatively safe for adolescent SD rats.
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影响因子：
3.6
作者：
Chen WC;Chen YM;Huang CC;Tzeng YD
通讯作者：
Tzeng YD
影响因子：
2.7
作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1146/annurev.anchem.1.031207.113026
发表时间：
2008-01-01
影响因子：
8
作者：
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通讯作者：
Nicholson, Jeremy K.
影响因子：
5.6
作者：
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