Short-term delayed recall of auditory verbal learning test is equivalent to long-term delayed recall for identifying amnestic mild cognitive impairment.
Short-term delayed recall of auditory verbal learning test is equivalent to long-term delayed recall for identifying amnestic mild cognitive impairment.
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听觉言语学习测试的短期延迟回忆与识别遗忘性轻度认知障碍的长期延迟回忆相同
DOI：
10.1371/journal.pone.0051157
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Guo Q
中科院分区：
文献类型：
--
作者：
Zhao Q;Lv Y;Zhou Y;Hong Z;Guo Q
在言语学习测试中，单词的延迟回忆是诊断遗忘型轻度认知障碍（aMCI）和早期阿尔茨海默病（AD）的敏感指标。延迟回忆的不同保持间隔的相对有效性尚未得到很好的表征。采用华山版听觉言语学习测验，比较短时延迟回忆（AVL-SR，即3 ~ 5 min的延迟时间）和长时延迟回忆（AVL-LR，即20 min的延迟时间）对aMCI（n = 897）和轻度AD（n = 530）患者与健康老年人（n = 1215）的区分价值。 在aMCI患者中，AVL-SR与AVL-LR的相关性非常高（r = 0.94），两项指标的差异小于0.5分。 AVL-SR和AVL-LR的零分率无差异。在受试者工作特征曲线分析中，虽然AVL-SR和AVL-LR诊断aMCI的曲线下面积（AUC）有显著差异，但两项指标的截断值相同。在80 ~ 89岁亚组中，两项指标的AUC差异无统计学意义。因此，我们得出结论，AVL-SR可以替代AVL-LR来识别aMCI，特别是对于年龄最大的患者。
Delayed recall of words in a verbal learning test is a sensitive measure for the diagnosis of amnestic mild cognitive impairment (aMCI) and early Alzheimer’s disease (AD). The relative validity of different retention intervals of delayed recall has not been well characterized. Using the Auditory Verbal Learning Test–Huashan version, we compared the differentiating value of short-term delayed recall (AVL-SR, that is, a 3- to 5-minute delay time) and long-term delayed recall (AVL-LR, that is, a 20-minute delay time) in distinguishing patients with aMCI (n = 897) and mild AD (n = 530) from the healthy elderly (n = 1215). In patients with aMCI, the correlation between AVL-SR and AVL-LR was very high (r = 0.94), and the difference between the two indicators was less than 0.5 points. There was no difference between AVL-SR and AVL-LR in the frequency of zero scores. In the receiver operating characteristic curves analysis, although the area under the curve (AUC) of AVL-SR and AVL-LR for diagnosing aMCI was significantly different, the cut-off scores of the two indicators were identical. In the subgroup of ages 80 to 89, the AUC of the two indicators showed no significant difference. Therefore, we concluded that AVL-SR could substitute for AVL-LR in identifying aMCI, especially for the oldest patients.
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