The analysis of commercially available natural products recommended for use in electronic cigarettes.
The analysis of commercially available natural products recommended for use in electronic cigarettes.
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DOI：
10.1002/rcm.8771
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发表时间：
2020-06-15
期刊：
影响因子：
--
通讯作者：
Poklis JL
中科院分区：
文献类型：
--
作者：
Peace MR;Smith ME;Poklis JL
天然植物产品已被用于促进健康，预防疾病和治疗各种疾病。这些产品通常由叶、花、树皮、根、种子和/或植物的其他部分组成。这些产品的许多活性成分是已知的，但这些成分的药理学可能还没有完全阐明。天然植物产品也可以以各种形式提供，而不是植物原料。各种各样的商业产品，如胶囊、粉末、提取物和电子烟（e-cigarettes）电子液体（e-liquid）是容易获得的，并且可以从各种商店、基于商店的零售商和在线购买。较新的电子烟通常被宣传为“加热而不燃烧”，并用于“蒸发”各种形式的提取物，包括“蜡”和“dabs”和植物原料。一家制造商被发现在网上销售“24种不同的草药”的粉末，提取物或电子液体。这些被宣传为“在美国法律的”，每种产品都列出了多种效果。购买了来自八种不同“草药”的八种电子液体、六种提取物（树脂）和四种粉末：非洲梦、槟榔、蓝莲花、Damiana、Kra图姆Na、Kra图姆Kok、Klip Dagga和野生Lettera。这些产品的广告说，“大多数人使用的叶子，粉末或树脂蒸发器”。使用真实的实时AccuTOF™质谱法（DART-MS）直接分析来鉴定天然产物中的精神活性组分。在八种电子液体中的两种、五种树脂中的三种和四种粉末中的三种中鉴定出的精神活性化合物是槟榔碱、槟榔碱、香豆素、恩他达胺、mitragynine、7-羟基mitragynine和荷叶碱。天然产品的粉末和树脂中含有精神活性物质和潜在有害物质。用于消费天然产品的新型电子烟可能会增加其滥用潜力。
Natural plant products have been used to promote health, prevent sickness, and treat various ailments. These products often consist of leaves, flowers, bark, roots, seeds and/or other parts of the plant. Many of the pharmacologically active constituents of these products are known, but the pharmacology of these constituents may not be fully elucidated. Natural plant-based products are also available in various forms other than the raw plant material. A wide array of commercial products such as capsules, powders, extracts, and electronic cigarette (e-cigarettes) electronic liquids (e-liquids) are readily available and can be purchased from various outlets, both store-based retailers and online. Newer e-cigarettes are often advertised as “heat not burn” and are used for “vaping” various forms of extracts including “waxes” and “dabs” and raw plant material. A single manufacturer was found online selling “24 different herbs” in powders, extracts or e-liquids. These were advertised as “legal in the USA” and each product listed multiple effects. Eight e-liquids, six extracts (resins), and four powders from eight different “herbs”: African Dream, Areca Nut, Blue Lotus, Damiana, Kra Thum Na, Kra Thum Kok, Klip Dagga, and Wild Lettuce, were purchased. An advertisement for these products stated, “Most people use the leaves, powder or resin in vaporizers”. Direct Analysis in Real Time AccuTOF™ Mass Spectrometry (DART-MS) was used to identify the psychoactive components in the natural products. The psychoactive compounds that were identified in only two of the eight e-liquids, three of the five resins and three of the four powders were arecaidine, arecoline, coumarin, entadamide, mitragynine, 7-hydroxymitragynine and nuciferine. Psychoactive and potentially harmful substances were present in the powders and resins of the natural products. The newer types of e-cigarettes made for consuming natural products may increase their abuse potential.
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影响因子：
5.4
作者：
Wesolowska, A.;Nikiforuk, A.;Chojnacka-Wojcik, E.
通讯作者：
Chojnacka-Wojcik, E.
影响因子：
5.2
作者：
Breland A;Soule E;Lopez A;Ramôa C;El-Hellani A;Eissenberg T
通讯作者：
Eissenberg T
影响因子：
4.1
作者：
Godoi, AFL;Vilegas, W;Van Grieken, R
通讯作者：
Van Grieken, R
影响因子：
0.9
作者：
Besharat, Sima;Besharat, Mahsa;Jabbari, Ali
通讯作者：
Jabbari, Ali
影响因子：
3.8
作者：
Nzowa, Laurence Kegah;Barboni, Luciano;Tapondjou, Leon Azefack
通讯作者：
Tapondjou, Leon Azefack