Survey of Saliva Components and Virus Sensors for Prevention of COVID-19 and Infectious Diseases.
Survey of Saliva Components and Virus Sensors for Prevention of COVID-19 and Infectious Diseases.
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DOI：
10.3390/bios11010014
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发表时间：
2020-12-31
期刊：
影响因子：
--
通讯作者：
Umpaichitra V
中科院分区：
文献类型：
--
作者：
Dave PK;Rojas-Cessa R;Dong Z;Umpaichitra V
美国疾病控制与预防中心认为唾液接触是严重急性呼吸综合征冠状病毒2（SARS - CoV - 2）的主要传播途径，该病毒引发了2019冠状病毒病（COVID - 19）。打喷嚏、咳嗽、呼吸和说话时喷出的唾液飞沫或气溶胶可能携带这种病毒。近距离的人可能直接接触这些飞沫，或者在接触到落在周围表面的飞沫后，再接触自己面部的黏膜组织而间接感染COVID - 19。快速有效地检测环境中SARS - CoV - 2的存在是非常有意义的，但据我们所知，现有的方法仅在实验室环境中有效。然而，检测环境中唾液的存在并采取预防措施是可能的。然而，文献中尚未有检测唾液本身的相关记载。另一方面，已经提出了许多检测唾液中不同有机成分以监测人的健康并诊断从糖尿病到口腔健康等不同疾病的传感器，它们可用于检测唾液的存在。本文综述了检测人类唾液中有机和无机成分的传感器。在唾液检测中也考虑了湿度传感器，因为唾液的很大一部分是水。此外，还包括检测传染性病毒的传感器，因为它们也可能嵌入唾液传感器中以确认病毒的存在。本文按传感器的工作原理及其检测的物质进行了分类，包括传感器的规格、样本量和灵敏度。指出了哪些传感器是便携式的且适合现场应用。本文还讨论了实现实用唾液传感器必须解决的未来研究方向和挑战。这类传感器可能不仅有助于最大限度地减少COVID - 19的传播，还有助于减少其他传染病的传播。
The United States Centers for Disease Control and Prevention considers saliva contact the lead transmission mean of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). Saliva droplets or aerosols expelled by sneezing, coughing, breathing, and talking may carry this virus. People in close distance may be exposed directly to these droplets or indirectly when touching the droplets that fall on surrounding surfaces and ending up contracting COVID-19 after touching the mucosa tissue of their faces. It is of great interest to quickly and effectively detect the presence of SARS-CoV-2 in an environment, but the existing methods only work in laboratory settings, to the best of our knowledge. However, it may be possible to detect the presence of saliva in the environment and proceed with prevention measures. However, detecting saliva itself has not been documented in the literature. On the other hand, many sensors that detect different organic components in saliva to monitor a person’s health and diagnose different diseases, ranging from diabetes to dental health, have been proposed and they may be used to detect the presence of saliva. This paper surveys sensors that detect organic and inorganic components of human saliva. Humidity sensors are also considered in the detection of saliva because a large portion of saliva is water. Moreover, sensors that detect infectious viruses are also included as they may also be embedded into saliva sensors for a confirmation of the presence of the virus. A classification of sensors by their working principles and the substances they detect is presented, including the sensors’ specifications, sample size, and sensitivity. Indications of which sensors are portable and suitable for field application are presented. This paper also discusses future research and challenges that must be resolved to realize practical saliva sensors. Such sensors may help minimize the spread of not only COVID-19 but also other infectious diseases.
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DOI：
10.3390/s17112495
发表时间：
2017-11-01
期刊：
Sensors (Basel, Switzerland)
影响因子：
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作者：
Dominguez RB;Orozco MA;Chávez G;Márquez-Lucero A
通讯作者：
Márquez-Lucero A
DOI：
10.3390/s17112597
发表时间：
2017-11-11
期刊：
Sensors (Basel, Switzerland)
影响因子：
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作者：
Devarakonda S;Singh R;Bhardwaj J;Jang J
通讯作者：
Jang J
DOI：
10.3390/s16122045
发表时间：
2016-12-01
期刊：
Sensors (Basel, Switzerland)
影响因子：
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作者：
Akiba U;Anzai JI
通讯作者：
Anzai JI
DOI：
10.3390/s90907431
发表时间：
2009
期刊：
Sensors (Basel, Switzerland)
影响因子：
--
作者：
Chen WP;Zhao ZG;Liu XW;Zhang ZX;Suo CG
通讯作者：
Suo CG
影响因子：
7
作者：
Gonzalez-Hernandez, Jorge M.;Franco, Lorena;Tvarijonaviciute, Asta
通讯作者：
Tvarijonaviciute, Asta