Multiparametric Renal Magnetic Resonance Imaging: Validation, Interventions, and Alterations in Chronic Kidney Disease.
Multiparametric Renal Magnetic Resonance Imaging: Validation, Interventions, and Alterations in Chronic Kidney Disease.
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DOI：
10.3389/fphys.2017.00696
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发表时间：
2017
影响因子：
4
通讯作者：
Francis ST
中科院分区：
文献类型：
--
作者：
Cox EF;Buchanan CE;Bradley CR;Prestwich B;Mahmoud H;Taal M;Selby NM;Francis ST
背景：本文概述了一种多参数肾脏MRI采集和分析方案，以允许对血流动力学(肾动脉血流和灌注)、氧合(BOLD T2*)和微结构(扩散、T1映射)进行无创评估。方法：我们使用我们的多参数肾脏MRI方案来提供(1)一组完整的MRI参数[肾动静脉血流量、血流灌注、T1、T2*、弥散(ADC、D、D*、FP)和肾脏总体积]，并显示MRI场强(1.5Tvs.3T)对T1和T2*松弛时间的依赖性；(2)11名健康受试者多参数MRI测量的可重复性；(3)6名健康受试者对高二氧化碳和高氧调节的响应；以及(4)显示多参数方案在11例慢性肾脏病(CKD)患者中的应用的试点数据。结果：基线测量结果与文献值一致，如预期的那样，T1值在3T比1.5T更长，在3T时T1皮髓分化增加，相反，在1.5T时T2*更长，T1标测和ADC的扫描间变异系数(CoVS)在2.9%非常好。皮质灌注(0.801)、皮质和髓质T1(SE-EPI分别为0.848和0.997)、肾动脉血流(0.844)的组内相关性(ICC)较高。在对高碳酸血症的反应中，观察到皮层T2*的减少，而高氧对T2*没有明显的影响。CKD患者的肾动、静脉血流量和肾血流灌注量均低于健康受试者。与健康受试者相比，CKD患者的肾皮质和髓质T1显著升高，皮髓T1分化程度降低。肾T2*无显著差异。结论：在单次扫描中，多参数MRI是评估结构、血流动力学和氧合变化的一种强有力的技术。该方案提供了评估肾脏疾病各种病因的病理生理学机制和评估药物治疗效果的可能性。
Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping). Methods: We use our multiparametric renal MRI protocol to provide (1) a comprehensive set of MRI parameters [renal artery and vein blood flow, perfusion, T1, T2*, diffusion (ADC, D, D*, fp), and total kidney volume] in a large cohort of healthy participants (127 participants with mean age of 41 ± 19 years) and show the MR field strength (1.5 T vs. 3 T) dependence of T1 and T2* relaxation times; (2) the repeatability of multiparametric MRI measures in 11 healthy participants; (3) changes in MRI measures in response to hypercapnic and hyperoxic modulations in six healthy participants; and (4) pilot data showing the application of the multiparametric protocol in 11 patients with Chronic Kidney Disease (CKD). Results: Baseline measures were in-line with literature values, and as expected, T1-values were longer at 3 T compared with 1.5 T, with increased T1 corticomedullary differentiation at 3 T. Conversely, T2* was longer at 1.5 T. Inter-scan coefficients of variation (CoVs) of T1 mapping and ADC were very good at <2.9%. Intra class correlations (ICCs) were high for cortex perfusion (0.801), cortex and medulla T1 (0.848 and 0.997 using SE-EPI), and renal artery flow (0.844). In response to hypercapnia, a decrease in cortex T2* was observed, whilst no significant effect of hyperoxia on T2* was found. In CKD patients, renal artery and vein blood flow, and renal perfusion was lower than for healthy participants. Renal cortex and medulla T1 was significantly higher in CKD patients compared to healthy participants, with corticomedullary T1 differentiation reduced in CKD patients compared to healthy participants. No significant difference was found in renal T2*. Conclusions: Multiparametric MRI is a powerful technique for the assessment of changes in structure, hemodynamics, and oxygenation in a single scan session. This protocol provides the potential to assess the pathophysiological mechanisms in various etiologies of renal disease, and to assess the efficacy of drug treatments.
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影响因子：
2.3
作者：
Gillis KA;McComb C;Foster JE;Taylor AH;Patel RK;Morris ST;Jardine AG;Schneider MP;Roditi GH;Delles C;Mark PB
通讯作者：
Mark PB
影响因子：
2.5
作者：
Dobre, Mircea C.;Ugurbil, Kamil;Marjanska, Malgorzata
通讯作者：
Marjanska, Malgorzata
影响因子：
3.3
作者：
Becker, HF;Polo, O;Sullivan, CE
通讯作者：
Sullivan, CE
DOI：
10.1097/01.rvi.0000161144.98350.28
发表时间：
2005-06-01
影响因子：
2.9
作者：
Bax, L;Bakker, CJG;Mali, WPTRM
通讯作者：
Mali, WPTRM
影响因子：
3.3
作者：
Gardener, Alexander G.;Francis, Susan T.
通讯作者：
Francis, Susan T.