Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis.
Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis.
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DOI：
10.1007/s10552-008-9283-x
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Kushi LH
中科院分区：
文献类型：
--
作者：
Bandera EV;Gifkins DM;Moore DF;McCullough ML;Kushi LH
Antioxidant vitamins may reduce cancer risk by limiting oxidative DNA damage. To summarize and quantify the current epidemiologic evidence of an association between antioxidant vitamin intake and endometrial cancer we conducted a systematic literature review and meta-analysis. One cohort and 12 case-control studies presenting relevant risk estimates were identified by conducting bibliographical searches through June 2008. Dose-response meta-analyses were conducted for beta-carotene, vitamin C, and vitamin E from food sources. Intake from supplements was not considered in the meta-analyses due to the few studies that reported relevant information. Based on case-control data, the random-effects summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79–0.98) per 1,000 mcg/1,000 kcal (I2: 77.7%; p <0.01); for vitamin C: 0.85 (95% CI: 0.73–0.98) per 50 mg / 1,000 kcal (I2: 66.1%; p <0.01); and, for vitamin E: 0.91 (95% CI: 0.84–0.99) per 5 mg / 1,000 kcal (I2: 0.0%; p:0.45). In contrast, the only prospective study identified provided little indication of an association. Although the current case-control data suggest an inverse relationship of endometrial cancer risk with dietary intakes of beta-carotene, vitamin C, and vitamin E from food sources, additional studies are needed, particularly cohort studies, to confirm an association.
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
7.1
作者：
KRINSKY, NI
通讯作者：
KRINSKY, NI
影响因子：
13.6
作者：
Jain, MG;Rohan, TE;Miller, AB
通讯作者：
Miller, AB
影响因子：
2.3
作者：
Bandera, Elisa V.;Kushi, Lawrence H.;McCullough, Marjorie L.
通讯作者：
McCullough, Marjorie L.
DOI：
10.1196/annals.1331.016
发表时间：
2004-01-01
期刊：
VITAMIN E AND HEALTH
影响因子：
--
作者：
Lunec, J;Halligan, E;Karakoula, K
通讯作者：
Karakoula, K