Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes.
Peripapillary vessel density correlates with visual field mean sensitivity in highly myopic eyes.
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DOI：
10.1186/s12967-022-03323-9
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发表时间：
2022-03-10
影响因子：
7.4
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Zhong H;Dong Q;Cun Q;He G;Tao Y;Song K;Lu Y;Zhu Q;Chen X;Chen Q
确定健康近视眼视乳头周围血管密度 (pVD) 的全局和区域分布，并尝试找出 pVD 与视野平均敏感度 (VFMS) 之间的关系。前瞻性横断面研究。本研究招募了来自两个临床中心的222名近视（近视屈光不正 < − 0.5屈光度）受试者，根据球镜当量（SE）分为4组：组1：− 0.5D ≥ SE > − 6.00D，组2： − 6.00D ≥ SE > − 8.00D，组3：− 8.00D ≥ SE > − 10.00D，组4：SE ≤ -10.00D。通过光学相干断层扫描血管造影（OCTA）评估的pVD在8中进行量化部门。使用 SD-OCT 进行视乳头周围视网膜神经纤维层 (pRNFL) 成像。视野 (VF) 测试是在 Humphrey 750i 视野分析仪上使用 30-2 SITA 标准程序进行的，并分为与结构匹配的 8 个区域。 pRNFL 在所有组中均无显着差异（p = 0.422）。第4组的平均pVD (47.61±6.58)显着低于第2组和第3组(分别为51.49±3.21、50.48±3.43)(p<0.05)。而组2和组3的pVD均显着低于组1（52.77±2.86）。第4组的平均VFMS（901.85±386.54）显着低于其他三组（第1、2、3组分别为1169.15±328.94、1081.77±338.83、1076.89±358.18）。 pVD和VFMS在组3（r = 0.184）和组4（r = 0.476）中呈正相关（p < 0.05）。线性回归分析表明，VFMS 与 pVD 呈正相关，尤其是在近视眼的颞象限和鼻象限中。在SE ≤ − 8.00D的高度近视眼中，pVD与VFMS呈显着正相关。我们认为 OCTA 测量 pVD 可能是监测近视功能变化的敏感且有用的方法。
To identify the global and regional distribution of peripapillary vessel density (pVD) and try to find out the relationships between pVD and the visual field mean sensitivity (VFMS) in healthy myopic eyes. Prospective cross-sectional study. Two hundred and twenty-two participants (393 eyes) with myopia (myopic refractive error < − 0.5 diopters) from two clinical centers were recruited in this study and were divided into 4 groups according to the spherical equivalent (SE): Group1:− 0.5D ≥ SE > − 6.00D, Group2: − 6.00D ≥ SE > − 8.00D, Group3:− 8.00D ≥ SE > − 10.00D, Group4:SE ≤ -10.00D.The pVD assessed with optical coherence tomography angiography (OCTA) was quantified in 8 sectors. Peripapillary retinal nerve fibre layer (pRNFL) imaging was performed with SD-OCT. Visual field (VF) tests were performed with the 30-2 SITA standard program on the Humphrey 750i Visual Field Analyzer and were grouped into 8 regions that matched the structure. The pRNFL had no significant difference in all groups (p = 0.422). The average pVD were significantly lower in group 4 (47.61 ± 6.58) than in group 2 and 3 (51.49 ± 3.21, 50.48 ± 3.43 respectively) (p < 0.05). While both pVD in group2 and 3 were statistically lower than group1 (52.77 ± 2.86). The average VFMS was significantly lower in group 4 (901.85 ± 386.54) than other three groups (1169.15 ± 328.94, 1081.77 ± 338.83, 1076.89 ± 358.18, for group1,2,3 respectively). The pVD and VFMS were positively correlated in group3 (r = 0.184) and group4 (r = 0.476) (p < 0.05). Linear regression analysis demonstrated that VFMS were positively associated with pVD especially in temporal and nasal quadrants in myopic eyes. The pVD shows a significant positive correlation with VFMS in highly myopic eyes with SE ≤ − 8.00D. We suggest that pVD measurement by OCTA could be a sensitive and useful method for monitoring myopic functional change.
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