Novel strategies for the prevention and treatment of biofilm related infections.
Novel strategies for the prevention and treatment of biofilm related infections.
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DOI：
10.3390/ijms140918488
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发表时间：
2013-09-06
影响因子：
5.6
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Chen M;Yu Q;Sun H
人体细菌病原体在植入的医疗器械上形成生物膜，导致患者的主要发病率和死亡率，并导致数十亿美元的医疗费用。生物膜是一种复杂的细菌群落，对抗生素和人体免疫力具有高度抗性。因此，迫切需要常规抗生素疗法以外的新的治疗解决方案。在本文中，我们将讨论最近在发现预防或治疗生物膜的替代方法方面的研究。目前的抗生物膜技术可以分为两类。第一组基于我们对生物膜形成的分子机制的理解，专注于靶向细菌的生物膜形成过程。已经开发了小分子和酶来抑制或破坏生物膜形成。另一组抗生物膜技术的重点是修改医疗器械中使用的生物材料，使其能够抵抗生物膜的形成。虽然这些新的抗生物膜方法仍处于发展的初期阶段，但致力于这些技术的努力最终可能导致上级当前抗生素治疗的抗生物膜疗法。
Biofilm formation by human bacterial pathogens on implanted medical devices causes major morbidity and mortality among patients, and leads to billions of dollars in healthcare cost. Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. As a result, novel therapeutic solutions other than the conventional antibiotic therapies are in urgent need. In this review, we will discuss the recent research in discovery of alternative approaches to prevent or treat biofilms. Current anti-biofilm technologies could be divided into two groups. The first group focuses on targeting the biofilm forming process of bacteria based on our understanding of the molecular mechanism of biofilm formation. Small molecules and enzymes have been developed to inhibit or disrupt biofilm formation. Another group of anti-biofilm technologies focuses on modifying the biomaterials used in medical devices to make them resistant to biofilm formation. While these novel anti-biofilm approaches are still in nascent phases of development, efforts devoted to these technologies could eventually lead to anti-biofilm therapies that are superior to the current antibiotic treatment.
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影响因子：
14
作者：
Antoci, Valentin, Jr.;Adams, Christopher S.;Parvizi, Javad;Davidson, Helen M.;Composto, Russell J.;Freeman, Theresa A.;Wickstrom, Eric;Ducheyne, Paul;Jungkind, Donald;Shapiro, Irving M.;Hickok, Noreen J.
通讯作者：
Hickok, Noreen J.
影响因子：
3.1
作者：
Fey PD;Olson ME
通讯作者：
Olson ME
影响因子：
9.9
作者：
Boks, Niels P.;Kaper, Hans J.;Busscher, Henk J.
通讯作者：
Busscher, Henk J.
影响因子：
3
作者：
Abraham, Nabil M.;Lamlertthon, Supaporn;Jefferson, Kimberly K.
通讯作者：
Jefferson, Kimberly K.
影响因子：
3.9
作者：
Huang, NP;Michel, R;Spencer, ND
通讯作者：
Spencer, ND