Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA).
Association of kidney function with inflammatory and procoagulant markers in a diverse cohort: a cross-sectional analysis from the Multi-Ethnic Study of Atherosclerosis (MESA).
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DOI：
10.1186/1471-2369-9-9
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发表时间：
2008-08-05
期刊：
影响因子：
2.3
通讯作者：
Shlipak, Michael
中科院分区：
文献类型：
--
作者：
Keller, Christopher;Katz, Ronit;Cushman, Mary;Fried, Linda F.;Shlipak, Michael
先前使用基于肌酐的估计肾小球滤过率（eGFR）的研究发现肾功能与炎症标志物之间的关联有限。作者使用 eGFR 和胱抑素 C（一种新的肾功能标志物）在不同队列中研究了肾功能与多种生物标志物的关联。动脉粥样硬化多种族研究由 2000 年至 2002 年期间从美国六个社区招募的 6,814 名参与者组成，其中包括白人、非裔美国人、西班牙裔和华裔。入组访视时的测量包括血清肌酐、半胱氨酸蛋白酶抑制剂 C 以及六种炎症和促凝血生物标志物。基于肌酐的 eGFR 使用肾脏疾病饮食四变量修正方程进行估计，慢性肾脏疾病的定义是 eGFR < 60 mL/min/1.73 m2。半胱氨酸蛋白酶抑制剂 C 与所有生物标志物之间调整后的部分相关性具有统计学显着性：C 反应蛋白 (r = 0.08)、白细胞介素 6 (r = 0.16)、肿瘤坏死因子 α 可溶性受体 1 (TNF-αR1；r = 0.75)、细胞间粘附分子 1 (r = 0.21)、纤维蛋白原 (r = 0.14) 和因子 VIII (r = 0.11；两侧 p < 0.01）。在没有慢性肾病的参与者中，较高的基于肌酐的 eGFR 仅与较高的 TNF-αR1 水平相关。在以种族多样性为特征的队列中，胱抑素 C 与多种促凝血和炎症标志物直接相关。在慢性肾病受试者中，基于肌酐的 eGFR 与这些生物标志物具有类似的关联。
Prior studies using creatinine-based estimated glomerular filtration rate (eGFR) have found limited associations between kidney function and markers of inflammation. Using eGFR and cystatin C, a novel marker of kidney function, the authors investigated the association of kidney function with multiple biomarkers in a diverse cohort. The Multi-Ethnic Study of Atherosclerosis consists of 6,814 participants of white, African-American, Hispanic, and Chinese descent, enrolled from 2000–2002 from six U.S. communities. Measurements at the enrollment visit included serum creatinine, cystatin C, and six inflammatory and procoagulant biomarkers. Creatinine-based eGFR was estimated using the four-variable Modification of Diet in Renal Disease equation, and chronic kidney disease was defined by an eGFR < 60 mL/min/1.73 m2. Adjusted partial correlations between cystatin C and all biomarkers were statistically significant: C-reactive protein (r = 0.08), interleukin-6 (r = 0.16), tumor necrosis factor-α soluble receptor 1 (TNF-αR1; r = 0.75), intercellular adhesion molecule-1 (r = 0.21), fibrinogen (r = 0.14), and factor VIII (r = 0.11; two-sided p < 0.01 for all). In participants without chronic kidney disease, higher creatinine-based eGFR was associated only with higher TNF-αR1 levels. In a cohort characterized by ethnic diversity, cystatin C was directly associated with multiple procoagulant and inflammatory markers. Creatinine-based eGFR had similar associations with these biomarkers among subjects with chronic kidney disease.
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影响因子：
2.8
作者：
Albert, MA;Glynn, RJ;Ridker, PM
通讯作者：
Ridker, PM
影响因子：
13.2
作者：
Coll, E;Botey, A;Darnell, A
通讯作者：
Darnell, A
影响因子：
19.6
作者：
Levey, AS;Eckardt, KU;Eknoyan, G
通讯作者：
Eknoyan, G
DOI：
10.1111/j.1432-1033.1988.tb14384.x
发表时间：
1988-11-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
CASTELL, JV;GEIGER, T;HEINRICH, PC
通讯作者：
HEINRICH, PC
影响因子：
3.8
作者：
BEMELMANS, MHA;GOUMA, DJ;BUURMAN, WA
通讯作者：
BUURMAN, WA