Cross-Sectional Association between Hypercholesterolemia and Knee Pain in the Elderly with Radiographic Knee Osteoarthritis: Data from the Korean National Health and Nutritional Examination Survey.
Cross-Sectional Association between Hypercholesterolemia and Knee Pain in the Elderly with Radiographic Knee Osteoarthritis: Data from the Korean National Health and Nutritional Examination Survey.
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高胆固醇血症与老年放射性膝关节骨关节炎患者膝关节疼痛的横断面相关性：来自韩国国家健康和营养检查调查的数据。
DOI：
10.3390/jcm10050933
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发表时间：
2021-03-01
影响因子：
3.9
通讯作者：
Park KK
中科院分区：
文献类型：
--
作者：
Cho BW;Kim DS;Kwon HM;Yang IH;Lee WS;Park KK
很少有研究报道膝关节疼痛和高胆固醇血症之间的关系，在老年人骨关节炎（OA），独立于其他变量。本研究的目的是通过大规模队列研究揭示膝关节疼痛与代谢性疾病（包括高胆固醇血症）之间的关系。使用韩国国民健康和营养检查调查（KNHANES-V，VI-1; 2010-2013）的数据进行了一项横断面研究。在年龄≥60岁的受试者中，7438例受试者（加权估计数= 35，524，307）回答了膝关节疼痛项目并进行了膝关节简单X线检查。使用多变量有序逻辑回归分析，确定影响膝关节疼痛的变量，并计算比值比（OR）。在35，524，307例受试者中，10，630，836例（29.9%）受试者发生膝关节疼痛。总体而言，20，290，421例受试者（56.3%）患有影像学OA，其中8，119，372例（40.0%）主诉膝关节疼痛。多变量有序逻辑回归分析显示，在代谢性疾病中，仅高胆固醇血症与OA组的膝关节疼痛呈正相关（OR 1.24; 95%置信区间1.02-1.52，p = 0.033）。在非OA组中没有与膝关节疼痛相关的代谢性疾病。这项大规模研究显示，在老年人中，高胆固醇血症与OA组的膝关节疼痛呈正相关，而与体重指数和其他代谢疾病无关，但在非OA组中则不然。这些结果将有助于了解关节炎疼痛的性质，并可能支持需要探索纵向协会。
Few studies have reported the relationship between knee pain and hypercholesterolemia in the elderly population with osteoarthritis (OA), independent of other variables. The aim of this study was to reveal the association between knee pain and metabolic diseases including hypercholesterolemia using a large-scale cohort. A cross-sectional study was conducted using data from the Korea National Health and the Nutrition Examination Survey (KNHANES-V, VI-1; 2010–2013). Among the subjects aged ≥60 years, 7438 subjects (weighted number estimate = 35,524,307) who replied knee pain item and performed the simple radiographs of knee were enrolled. Using multivariable ordinal logistic regression analysis, variables affecting knee pain were identified, and the odds ratio (OR) was calculated. Of the 35,524,307 subjects, 10,630,836 (29.9%) subjects experienced knee pain. Overall, 20,290,421 subjects (56.3%) had radiographic OA, and 8,119,372 (40.0%) of them complained of knee pain. Multivariable ordinal logistic regression analysis showed that among the metabolic diseases, only hypercholesterolemia was positively correlated with knee pain in the OA group (OR 1.24; 95% Confidence Interval 1.02–1.52, p = 0.033). There were no metabolic diseases correlated with knee pain in the non-OA group. This large-scale study revealed that in the elderly, hypercholesterolemia was positively associated with knee pain independent of body mass index and other metabolic diseases in the OA group, but not in the non-OA group. These results will help in understanding the nature of arthritic pain, and may support the need for exploring the longitudinal associations.
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影响因子：
4.9
作者：
Larrañaga-Vera A;Lamuedra A;Pérez-Baos S;Prieto-Potin I;Peña L;Herrero-Beaumont G;Largo R
通讯作者：
Largo R
影响因子：
2.3
作者：
Bedson, John;Croft, Peter R.
通讯作者：
Croft, Peter R.
影响因子：
7
作者：
Jorgensen, K. T.;Pedersen, B. V.;Frisch, M.
通讯作者：
Frisch, M.
影响因子：
27.4
作者：
Clockaerts, S.;Van Osch, G. J. V. M.;Bierma-Zeinstra, S. M.
通讯作者：
Bierma-Zeinstra, S. M.
影响因子：
27.4
作者：
Riddle, Daniel L.;Moxley, George;Dumenci, Levent
通讯作者：
Dumenci, Levent