Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies.
Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies.
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DOI：
10.1111/jam.15225
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发表时间：
2022-01
影响因子：
4
通讯作者：
Kharel MK
中科院分区：
文献类型：
--
作者：
Ossai J;Khatabi B;Nybo SE;Kharel MK
放线菌是生物活性分子的丰富来源。传统的工作流程包括细菌分离、发酵、代谢物鉴定和结构阐明，近年来导致了天然产物的高再发现率。近年来，多组学技术的进步揭示了放线菌基因组中的隐藏基因簇，为研究生物活性分子提供了潜在的资源。虽然培养技术的发展使难以培养的放线菌发酵成为可能，但高通量代谢物筛选为加速发现热门药物提供了全面的工具。从独特环境来源的放线菌中，如内生放线菌和共生放线菌中分离出了多种新的生物活性分子。合成生物学和基因组挖掘也成为发现生物活性分子的新领域。本文综述了放线菌衍生天然产物药物的最新研究进展。
Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including bacterial isolation, fermentation, metabolite identification, and structure elucidation have resulted in high rates of natural product rediscovery in recent years. Recent advancements in multi-omics techniques have uncovered cryptic gene clusters within the genomes of actinomycetes, potentially introducing vast resources for the investigation of bioactive molecules. While developments in culture techniques have allowed for the fermentation of difficult-to-culture actinomycetes, high throughput metabolite screening has offered plenary tools to accelerate hits discovery. A variety of new bioactive molecules have been isolated from actinomycetes of unique environmental origins, such as endophytic and symbiotic actinomycetes. Synthetic biology and genome mining have also emerged as new frontiers for the discovery of bioactive molecules. This review covers the highlights of recent developments in actinomycete-derived natural product drug discovery.
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