Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis.
Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis.
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ADIPOQ 三种常见单核苷酸多态性（rs266729、rs2241766 和 rs1501299）与心血管疾病之间的关联：荟萃分析
DOI：
10.1186/s12944-018-0767-8
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发表时间：
2018-05-28
影响因子：
4.5
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Kanu JS;Qiu S;Cheng Y;Li R;Kou C;Gu Y;Bai Y;Shi J;Li Y;Liu Y;Yu Y;Liu Y
关于心血管疾病（CVD）与脂联素（ADIPOQ）单核苷酸多态性（SNPs）之间关联的研究结果存在不一致性，这引发了本次最新的荟萃分析。
我们在PubMed、EMBASE、Cochrane图书馆、中国知网、中国生物医学文献数据库、维普和万方数据库中检索了截至2017年7月1日的相关研究。在本次荟萃分析中，我们纳入了来自65篇已发表文章的19106例病例和31629例对照。所有统计分析均使用STATA 12.0软件。
我们的结果显示，在显性模型或杂合子模型中，rs266729多态性与心血管疾病风险增加相关；在遗传模型（等位基因、显性、隐性、杂合子和纯合子）中，rs2241766多态性与心血管疾病风险增加相关。在亚组分析中，发现这三个SNPs在不同亚组中存在显著关联。荟萃回归和亚组分析表明，异质性可能由其他混杂因素解释。敏感性分析显示我们的荟萃分析结果稳定且可靠。此外，试验序贯分析结果表明我们的结果证据足以得出明确结论。
总之，我们的荟萃分析发现心血管疾病风险显著增加与rs266729和rs2241766相关，但与rs1501299无关。
本文的网络版（10.1186/s12944 - 018 - 0767 - 8）包含补充材料，授权用户可获取。
Inconsistencies have existed in research findings on the association between cardiovascular disease (CVD) and single nucleotide polymorphisms (SNPs) of ADIPOQ, triggering this up-to-date meta-analysis. We searched for relevant studies in PubMed, EMBASE, Cochrane Library, CNKI, CBM, VIP, and WanFang databases up to 1st July 2017. We included 19,106 cases and 31,629 controls from 65 published articles in this meta-analysis. STATA 12.0 software was used for all statistical analyses. Our results showed that rs266729 polymorphism was associated with the increased risk of CVD in dominant model or in heterozygote model; rs2241766 polymorphism was associated with the increased risk of CVD in the genetic models (allelic, dominant, recessive, heterozygote, and homozygote). In subgroup analysis, significant associations were found in different subgroups with the three SNPs. Meta-regression and subgroup analysis showed that heterogeneity might be explained by other confounding factors. Sensitivity analysis revealed that the results of our meta-analysis were stable and robust. In addition, the results of trial sequential analysis showed that evidences of our results are sufficient to reach concrete conclusions. In conclusion, our meta-analysis found significant increased CVD risk is associated with rs266729 and rs2241766, but not associated with rs1501299.
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影响因子：
2
作者：
Jung, Chan-Hee;Rhee, Eun-Jung;Park, Jung-Roe
通讯作者：
Park, Jung-Roe
影响因子：
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作者：
Higgins, Julian P. T.;Whitehead, Anne;Simmonds, Mark
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影响因子：
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作者：
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通讯作者：
Bhatnagar A
影响因子：
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通讯作者：
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作者：
Ji, Fuling;Ning, Feng;Silventoinen, Karri
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Silventoinen, Karri