Association of Adiponectin Gene Polymorphisms With the Risk of Coronary Artery Disease in Patients With Nonalcoholic Fatty Liver Disease in a Chinese Han Population.
Association of Adiponectin Gene Polymorphisms With the Risk of Coronary Artery Disease in Patients With Nonalcoholic Fatty Liver Disease in a Chinese Han Population.
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DOI：
10.5812/hepatmon.37388
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发表时间：
2016-07
影响因子：
0.6
通讯作者：
Xin YN
中科院分区：
文献类型：
--
作者：
Du SX;Lu LL;Liu Y;Dong QJ;Xuan SY;Xin YN
心血管事件是非酒精性脂肪性肝病(NAFLD)的独立危险因素，NAFLD是NAFLD患者死亡的主要原因。近年来的研究表明，脂联素(Adponectin，Ad)基因多态性与非酒精性脂肪性肝病(NAFLD)和冠状动脉疾病(CAD)的进展有关。然而，在中国北方汉族人群中，缺乏关于AD基因多态与NAFLD患者发生冠心病风险的相关性的报道。本研究旨在探讨AD基因(rs266729和rs2241766)多态性与北方汉族NAFLD患者发生冠心病风险的关系。在这项病例对照研究中，采用聚合酶链式反应(PCR)技术，对经B超证实的NAFLD患者、合并冠心病(n=246)和不合并冠心病(n=247)的患者和健康对照组(n=304)进行Adrs266729和rs2241766基因多态性分析。用生化方法测定血脂谱。采用SPSS17.0统计软件进行统计分析。NAFLD合并冠心病组与非冠心病组Adrs266729 G等位基因频率差异有统计学意义(P<；0.05)。NAFLD组Adrs2241766 G等位基因与对照组比较差异有统计学意义(P<；0.05)。在NAFLD CAD人群中，携带Adrs266729 G等位基因携带者的血清甘油三酯、总胆固醇、空腹血糖和低密度脂蛋白水平高于非携带者(P=0.031，P=0.034，P=0.007，P<0.001)，而AD水平低于非携带者(P<；0.001)。无冠心病的非酒精性脂肪肝患者的甘油三酯和空腹血糖水平高于非携带者(P=0.014，P=0.038)，AD水平低于非携带者(P<0.001)。在伴有和不伴有冠心病的非酒精性脂肪肝患者中，携带Adrs2241766 G等位基因携带者的甘油三酯水平高于非携带者(P=0.039和P=0.042)。在中国北方汉族人群中，Adrs266729和rs2241766 G等位基因与NAFLD的发生密切相关。然而，只有携带Adrs266729G等位基因的NAFLD患者发生冠心病的风险增加。
Cardiovascular events are an independent risk factor for nonalcoholic fatty liver disease (NAFLD), which is the leading cause of mortality in NAFLD patients. Several recent studies demonstrated that adiponectin (Ad) polymorphisms were involved in the progression of NAFLD and coronary artery disease (CAD). However, reports on the association between Ad polymorphisms and the risk of developing CAD in NAFLD patients are lacking in a Northern Han Chinese population. The present study was designed to evaluate the association between Ad gene polymorphisms (rs266729 and rs2241766) and the risk of developing CAD in Northern Han Chinese patients with NAFLD. In this case-control study, using the polymerase chain reaction (PCR), Adrs266729 and rs2241766 gene polymorphisms were genotyped in B-type ultrasonography-proven NAFLD patients, with (n = 246) or without (n = 247) CAD and in healthy controls (n = 304). Serum lipid profiles were determined using biochemical methods. Statistical analyses were performed using SPSS 17.0 statistical software. There were significant differences in the Adrs266729 G allele between the NAFLD patients with and without CAD (P < 0.05). In addition, there was a significant difference in the Adrs2241766 G allele of the NAFLD patients compared with that of the controls (P < 0.05). In the NAFLD CAD population, carriers of the G allele of Adrs266729 had higher serum triglycerides (TG), total cholesterol (TC), fasting plasma glucose (FPG), and low-density lipoprotein (LDL) levels and a lower Ad level than their noncarrier counterparts (P = 0.031, P = 0.034, P = 0.007, P < 0.001, and P < 0.001, respectively). NAFLD patients without CAD had higher TG and serum FPG values and a lower Ad level than their noncarrier counterparts (P = 0.014, P = 0.038, and P < 0.001, respectively). In the NAFLD patients with/without CAD, the carriers of the G allele of Adrs2241766 had higher TG levels (P = 0.039 and P = 0.042, respectively) than those of their noncarrier counterparts. In this Northern Chinese Han population, the Adrs266729 and rs2241766 G alleles were closely associated with the occurrence of NAFLD. However, only NAFLD patients who carried the Adrs266729 G allele had an increased risk of developing CAD.
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影响因子：
9.3
作者：
Tong G;Wang N;Leng J;Tong X;Shen Y;Yang J;Ye X;Zhou L;Zhou Y
通讯作者：
Zhou Y
影响因子：
0.6
作者：
Hashemi M;Hanafi Bojd H;Eskandari Nasab E;Bahari A;Hashemzehi NA;Shafieipour S;Narouie B;Taheri M;Ghavami S
通讯作者：
Ghavami S
影响因子：
1.9
作者：
Abenavoli, Ludovico;Peta, Valentina
通讯作者：
Peta, Valentina
影响因子：
5.8
作者：
Hermann, TS;Li, WJ;Torp-Pedersen, C
通讯作者：
Torp-Pedersen, C
影响因子：
9.8
作者：
Jee, Sun Ha;Sull, Jae Woong;Beaty, Terri H.
通讯作者：
Beaty, Terri H.