Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus
Morphological analysis of the cerebellum and its efferent system in a basal actinopterygian fish, Polypterus senegalus
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基础放线鱼塞内加尔小脑及其传出系统的形态分析
DOI：
10.1002/cne.25271
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发表时间：
2022
影响因子：
2.5
通讯作者：
Hibi Masahiko
中科院分区：
文献类型：
--
作者：
Ikenaga Takanori;Shimomai Rinko;Hagio Hanako;Kimura Satoru;Matsumoto Kazumasa;Kato Dai‐ichiro;Uesugi Kentaro;Takeuchi Akihisa;Yamamoto Naoyuki;Hibi Masahiko
尽管所有脊椎动物的小脑都含有颗粒细胞、浦肯野细胞和传出神经元，但细胞排列和神经回路高度多样化。小脑传出神经元形成簇，位于小脑深部的小脑核，接受来自浦肯野细胞的突触输入，但不接受颗粒细胞的突触输入。然而，在硬骨鱼类的小脑，传出神经元，称为广突细胞，位于浦肯野细胞的胞体附近，并接受来自浦肯野细胞轴突和颗粒细胞平行纤维的输入。在很大程度上不知道小脑结构是如何在鳍鱼（辐鳍鱼）中进化的。为了解决这个问题，我们分析了小脑的bichirPolypterus seneparus，最基础的放线菌之一。我们发现浦肯野细胞的胞体并不排列成一层，传入的攀爬纤维主要终止于浦肯野细胞的基底部，揭示了多翅虫小脑在脊椎动物小脑中具有独特的特征。逆行标记和标记物分析的传出神经元显示，它们的细胞体位于有限的颗粒区，但不是作为深小脑核的小脑白色物质。传出神经元具有长树突，类似广突细胞，尽管它们没有到达分子层。我们的研究结果表明，bichir小脑的传出系统之间的硬骨鱼和脊椎动物的中间功能，并提供了一个模型，以了解的基础上产生的多样性在actinopterygian小脑。
Although all vertebrate cerebella contain granule cells, Purkinje cells, and efferent neurons, the cellular arrangement and neural circuitry are highly diverse. In amniotes, cerebellar efferent neurons form clusters, deep cerebellar nuclei, lie deep in the cerebellum, and receive synaptic inputs from Purkinje cells but not granule cells. However, in the cerebellum of teleosts, the efferent neurons, called eurydendroid cells, lie near the cell bodies of Purkinje cells and receive inputs both from axons of Purkinje cells and granule cell parallel fibers. It is largely unknown how the cerebellar structure evolved in ray‐finned fish (actinopterygians). To address this issue, we analyzed the cerebellum of a bichirPolypterus senegalus, one of the most basal actinopterygians. We found that the cell bodies of Purkinje cells are not aligned in a layer; incoming climbing fibers terminate mainly on the basal portion of Purkinje cells, revealing that thePolypteruscerebellum has unique features among vertebrate cerebella. Retrograde labeling and marker analyses of the efferent neurons revealed that their cell bodies lie in restricted granular areas but not as deep cerebellar nuclei in the cerebellar white matter. The efferent neurons have long dendrites like eurydendroid cells, although they do not reach the molecular layer. Our findings suggest that the efferent system of the bichir cerebellum has intermediate features between teleosts and amniote vertebrates, and provides a model to understand the basis generating diversity in actinopterygian cerebella.
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硬骨鱼（Oreochromis niloticus）尾部小脑体的纤维连接，特别是内在电路
DOI：
--
发表时间：
2017
期刊：
Brain, Behavior and Evolution
影响因子：
--
作者：
K. Imura;N. Yamamoto;M. Yoshimoto;Masato Endo;K. Funakoshi;Hironobu Ito
通讯作者：
Hironobu Ito
影响因子：
2.5
作者：
Jesús M. López;D. Lozano;R. Morona;Agustín González
通讯作者：
Jesús M. López;D. Lozano;R. Morona;Agustín González
影响因子：
2.7
作者：
Kani, Shuichi;Bae, Young-Ki;Hibi, Masahiko
通讯作者：
Hibi, Masahiko
作者对“基础放线鱼塞内加尔多鳍鱼小脑及其传出系统的形态分析”的回复
DOI：
10.1002/cne.25271/v2/response1
发表时间：
2021
期刊：
影响因子：
--
作者：
Takanori Ikenaga;Rinko Shimomai;Hanako Hagio;Satoru Kimura;Kazumasa Matsumoto;Dai‐ichiro Kato;Kentaro Uesugi;Akihisa Takeuchi;Naoyuki Yamamoto;Masahiko Hibi
通讯作者：
Masahiko Hibi
影响因子：
3.3
作者：
Hioki, H;Fujiyama, F;Kaneko, T
通讯作者：
Kaneko, T