Conspicuity and muscle-invasiveness assessment for bladder cancer using VI-RADS: a multi-reader, contrast-free MRI study to determine optimal b-values for diffusion-weighted imaging.
Conspicuity and muscle-invasiveness assessment for bladder cancer using VI-RADS: a multi-reader, contrast-free MRI study to determine optimal b-values for diffusion-weighted imaging.
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DOI：
10.1007/s00261-022-03490-9
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发表时间：
2022-05
影响因子：
2.4
通讯作者：
Caulo, Massimo
中科院分区：
文献类型：
--
作者：
Pizzi, Andrea Delli;Mastrodicasa, Domenico;Taraschi, Alessio;Civitareale, Nicoletta;Mincuzzi, Erica;Censi, Stefano;Marchioni, Michele;Primiceri, Giulia;Castellan, Pietro;Castellucci, Roberto;Cocco, Giulio;Chiacchiaretta, Piero;Colasante, Antonella;Corvino, Antonio;Schips, Luigi;Caulo, Massimo
旨在（1）使用基于膀胱成像报告和数据系统（VI-RADS）的无对比方法比较三个b值之间的膀胱癌（BC）肌肉侵袭性，（2）确定肌肉侵袭性评估是否受阅片者经验的影响，以及（3）定性和定量比较三个b值之间的BC显著性。入组了38名在3.0 T扫描仪上接受膀胱MRI的患者。金标准是经尿道切除BC后的组织病理学报告。三组图像，包括T2 w和DWI的不同b值，第1组（B = 1000 s/mm 2）、第2组（B = 1500 s/mm 2）和第3组（B = 2000 s/mm 2），由三名经验不同的阅片人进行审查。计算描述性统计量和组内相关系数（ICC）。采用Wilcoxon检验对阅片师和DWI集进行比较。进行受试者工作特征（ROC）分析。计算曲线下面积（AUC）和成对比较。肌肉侵袭性评估的AUC范围为0.896 - 0.984（阅片人1）、0.952-0.968（阅片人2）和0.952-0.984（阅片人3），不同组和阅片人之间无显著差异（p > 0.05）。组1的平均显著性定性评分较高（2.21-2.33），其次是组2（2-2.16）和组3（1.82-2.14）。定量显著性评估显示，第2组（4.217-4.737）的平均标准化肿瘤强度显著高于第1组（3.923-4.492）和第3组（3.833-3.992）（p < 0.05）。无论阅片者的经验如何，使用T2 W和DWI的无对比协议都可以高精度地评估肌肉侵入性。B = 1500 s/mm 2显示了最佳的肿瘤轮廓，而B = 1000 s/mm 2允许更好的肿瘤-壁界面评估。
To (1) compare bladder cancer (BC) muscle invasiveness among three b-values using a contrast-free approach based on Vesical Imaging-Reporting and Data System (VI-RADS), to (2) determine if muscle-invasiveness assessment is affected by the reader experience, and to (3) compare BC conspicuity among three b-values, qualitatively and quantitatively. Thirty-eight patients who underwent a bladder MRI on a 3.0-T scanner were enrolled. The gold standard was histopathology report following transurethral resection of BC. Three sets of images, including T2w and different b-values for DWI, set 1 (b = 1000 s/mm2), set 2 (b = 1500 s/mm2), and set 3 (b = 2000 s/mm2), were reviewed by three differently experienced readers. Descriptive statistics and Intraclass Correlation Coefficient (ICC) were calculated. Comparisons among readers and DWI sets were performed with the Wilcoxon test. Receiver operating characteristic (ROC) analysis was performed. Areas under the curves (AUCs) and pairwise comparison were calculated. AUCs of muscle-invasiveness assessment ranged from 0.896 to 0.984 (reader 1), 0.952–0.968 (reader 2), and 0.952–0.984 (reader 3) without significant differences among different sets and readers (p > 0.05). The mean conspicuity qualitative scores were higher in Set 1 (2.21–2.33), followed by Set 2 (2–2.16) and Set 3 (1.82–2.14). The quantitative conspicuity assessment showed that mean normalized intensity of tumor was significantly higher in Set 2 (4.217–4.737) than in Set 1 (3.923–4.492) and Set 3 (3.833–3.992) (p < 0.05). Muscle invasiveness can be assessed with high accuracy using a contrast-free protocol with T2W and DWI, regardless of reader’s experience. b = 1500 s/mm2 showed the best tumor delineation, while b = 1000 s/mm2 allowed for better tumor–wall interface assessment.
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影响因子：
1.3
作者：
Rosa, C.;Caravatta, L.;Genovesi, D.
通讯作者：
Genovesi, D.
影响因子：
2.4
作者：
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DOI：
10.1016/j.urolonc.2019.05.020
发表时间：
2019-12-01
影响因子：
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