The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage.
The intrathecal CD163-haptoglobin-hemoglobin scavenging system in subarachnoid hemorrhage.
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DOI：
10.1111/j.1471-4159.2012.07716.x
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发表时间：
2012-06
影响因子：
4.7
通讯作者：
Galea I
中科院分区：
文献类型：
--
作者：
Galea J;Cruickshank G;Teeling JL;Boche D;Garland P;Perry VH;Galea I
细胞外血红蛋白引起的迟发性脑缺血是蛛网膜下腔出血预后的重要决定因素。血红蛋白在循环中被CD 163-触珠蛋白系统清除，但对人类CNS中的这种清除途径知之甚少。在正常脑脊液和蛛网膜下腔出血后分析了该系统的组成部分。明确证明了鞘内存在CD 163-触珠蛋白-血红蛋白清除系统。正常CNS中CD 163-触珠蛋白-血红蛋白系统的静息容量比循环低50 000倍。蛛网膜下腔出血后，鞘内CD 163-触珠蛋白-血红蛋白系统饱和，尽管可检测到触珠蛋白，但仍存在细胞外血红蛋白。来自CNS的血红蛋白流出是明显的，使得能够通过体循环清除救援血红蛋白。因此，CNS不能处理显著的鞘内溶血。预防迟发性脑缺血的潜在治疗选择应该集中在增加鞘内CD 163-触珠蛋白-血红蛋白清除系统的能力和鼓励血红蛋白从大脑流出的策略上。
Delayed cerebral ischemia resulting from extracellular hemoglobin is an important determinant of outcome in subarachnoid hemorrhage. Hemoglobin is scavenged by the CD163-haptoglobin system in the circulation, but little is known about this scavenging pathway in the human CNS. The components of this system were analyzed in normal cerebrospinal fluid and after subarachnoid hemorrhage. The intrathecal presence of the CD163-haptoglobin–hemoglobin scavenging system was unequivocally demonstrated. The resting capacity of the CD163-haptoglobin–hemoglobin system in the normal CNS was 50 000-fold lower than that of the circulation. After subarachnoid hemorrhage, the intrathecal CD163-haptoglobin–hemoglobin system was saturated, as shown by the presence of extracellular hemoglobin despite detectable haptoglobin. Hemoglobin efflux from the CNS was evident, enabling rescue hemoglobin scavenging by the systemic circulation. Therefore, the CNS is not capable of dealing with significant intrathecal hemolysis. Potential therapeutic options to prevent delayed cerebral ischemia ought to concentrate on augmenting the capacity of the intrathecal CD163-haptoglobin–hemoglobin scavenging system and strategies to encourage hemoglobin efflux from the brain.
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影响因子：
20.3
作者：
Moller, HJ;Peterslund, NA;Moestrup, SK
通讯作者：
Moestrup, SK
影响因子：
4.4
作者：
Chamoun, V;Zeman, A;Thompson, EJ
通讯作者：
Thompson, EJ
影响因子：
4
作者：
Rapoport, SI
通讯作者：
Rapoport, SI
影响因子：
1.9
作者：
Pluta, Ryszard M.;Hansen-Schwartz, Jacob;Zhang, John H.
通讯作者：
Zhang, John H.
DOI：
10.1038/jcbfm.2009.19
发表时间：
2009-05
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Li RC;Saleem S;Zhen G;Cao W;Zhuang H;Lee J;Smith A;Altruda F;Tolosano E;Doré S
通讯作者：
Doré S