Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva.
Suppressed prefrontal cortex oscillations associate with clinical pain in fibrodysplasia ossificans progressiva.
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DOI：
10.1186/s13023-021-01709-4
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发表时间：
2021-01-30
影响因子：
3.7
通讯作者：
Upadhyay J
中科院分区：
文献类型：
--
作者：
Peng K;Karunakaran KD;Labadie R;Veliu M;Cheung C;Lee A;Yu PB;Upadhyay J
疼痛是许多罕见肌肉骨骼疾病患者经历的一种非常普遍的症状。关于肌肉骨骼疾病状态下与临床疼痛相关的中枢神经生物学过程仍有许多未知之处。进行性骨化性纤维发育不良（FOP）是一种遗传性疾病，其特征是严重的身体残疾和疼痛。FOP由骨形态发生蛋白（BMP）受体激活素A受体1型（ACVR 1）突变引起，导致患者经历疼痛发作以及骨骼肌、肌腱、韧带和筋膜的异位骨化（HO）。迄今为止，FOP疼痛的神经生物学过程很少被研究。我们研究疼痛和中枢疼痛机制FOP作为一个模型的主要肌肉骨骼条件。使用功能性近红外光谱（fNIRS）对FOP患者（N = 17）的中枢神经系统（CNS）功能特性进行了研究，这些患者分为低（0-3; 0-10量表）和高（≥ 4）疼痛队列。临床疼痛，心理健康和身体健康之间的关联也进行了量化，使用来自一组临床问卷的响应。静息状态fNIRS显示，在高疼痛FOP患者的前额叶皮层中，慢5频率子带（0.01-0.027 Hz）内的血流动力学活动的功率受到抑制，其中，慢5，前额叶皮层振荡的功率降低与疼痛水平呈显著负相关。较高的临床疼痛强度也与较高程度的抑郁症状有关。我们的研究结果不仅证明了前额叶皮层功能和FOP临床疼痛之间的强大耦合，而且为利用fNIRS客观地监测FOP和其他肌肉骨骼疾病的中枢疼痛机制奠定了基础。
Pain is a highly prevalent symptom experienced by patients across numerous rare musculoskeletal conditions. Much remains unknown regarding the central, neurobiological processes associated with clinical pain in musculoskeletal disease states. Fibrodysplasia ossificans progressiva (FOP) is an inherited condition characterized by substantial physical disability and pain. FOP arises from mutations of the bone morphogenetic protein (BMP) receptor Activin A receptor type 1 (ACVR1) causing patients to undergo painful flare-ups as well as heterotopic ossification (HO) of skeletal muscles, tendons, ligaments, and fascia. To date, the neurobiological processes that underlie pain in FOP have rarely been investigated. We examined pain and central pain mechanism in FOP as a model primary musculoskeletal condition. Central nervous system (CNS) functional properties were investigated in FOP patients (N = 17) stratified into low (0–3; 0–10 Scale) and high (≥ 4) pain cohorts using functional near-infrared spectroscopy (fNIRS). Associations among clinical pain, mental health, and physical health were also quantified using responses derived from a battery of clinical questionnaires. Resting-state fNIRS revealed suppressed power of hemodynamic activity within the slow-5 frequency sub-band (0.01–0.027 Hz) in the prefrontal cortex in high pain FOP patients, where reduced power of slow-5, prefrontal cortex oscillations exhibited robust negative correlations with pain levels. Higher clinical pain intensities were also associated with higher magnitudes of depressive symptoms. Our findings not only demonstrate a robust coupling among prefrontal cortex functionality and clinical pain in FOP but lays the groundwork for utilizing fNIRS to objectively monitor and central pain mechanisms in FOP and other musculoskeletal disorders.
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影响因子：
3.7
作者：
Baujat G;Choquet R;Bouée S;Jeanbat V;Courouve L;Ruel A;Michot C;Le Quan Sang KH;Lapidus D;Messiaen C;Landais P;Cormier-Daire V
通讯作者：
Cormier-Daire V
DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
功能连接和局部脑血流的耦合揭示了人脑网络枢纽的生理基础
DOI：
10.1073/pnas.1214900110
发表时间：
2013-01-29
影响因子：
11.1
作者：
Liang, Xia;Zou, Qihong;Yang, Yihong
通讯作者：
Yang, Yihong
影响因子：
3.1
作者：
Naylor, Jennifer C.;Wagner, H. Ryan;Strauss, Jennifer L.
通讯作者：
Strauss, Jennifer L.
影响因子：
25
作者：
Malvaez, Melissa;Shieh, Christine;Wassum, Kate M.
通讯作者：
Wassum, Kate M.