Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis
Higher Serum CCN3 Is Associated with Disease Activity and Inflammatory Markers in Rheumatoid Arthritis
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较高的血清 CCN3 与类风湿关节炎的疾病活动性和炎症标志物相关
DOI：
10.1155/2020/3891425
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发表时间：
2020-05
影响因子：
4.1
通讯作者：
Chen Jie
中科院分区：
文献类型：
--
作者：
Wei Yingying;Peng Linan;Li Yi;Zhang Na;Shang Ke;Duan Lihua;Zhong Jixin;Chen Jie
肾母细胞瘤过表达蛋白 (NOV/CCN3) 是早期发现的 CCN 家族成员，最近被认为参与许多炎症过程，包括伤口愈合、肺泡上皮细胞炎症、癌症转移和巨噬细胞泡沫细胞形成。然而，CCN3 在类风湿性关节炎 (RA) 这种典型的自身免疫和炎症性疾病中的作用仍然难以捉摸。 RA是一种慢性全身性自身免疫性疾病，最终导致软骨和骨质破坏以及关节功能障碍。在这项研究中，我们研究了血清 CCN3 作为 RA 生物标志物的潜力。通过ELISA测定CCN3的血清水平。从临床记录系统收集临床和实验室参数，并通过关节疾病活动评分 28 (DAS28) 确定疾病活动度。我们的结果表明，与健康对照相比，RA 患者的 CCN3 血清水平显着升高。此外，CCN3水平与DAS28（CRP）、DAS28（ESR）和抗CCP抗体（一种对RA高度特异性的自身抗体）的水平呈正相关。此外，CCN3与炎症细胞因子IL-6呈正相关，而与TNF-α则无显着相关性。这些数据表明CCN3在RA的发展中发挥着重要作用，并且可能是RA的潜在疾病活动生物标志物。
Nephroblastoma overexpressed protein (NOV/CCN3), the early discovered member of the CCN family, has recently been suggested to be involved in a number of inflammatory processes, including wound healing, alveolar epithelial cell inflammation, cancer metastasis, and macrophage foam cell formation. However, the role of CCN3 in rheumatoid arthritis (RA), a classic autoimmune and inflammatory disease, remains elusive. RA is a chronic systemic autoimmune disease that eventually leads to cartilage and bone destruction and joint dysfunction. In this study, we investigated the potential of serum CCN3 as a biomarker for RA. The serum levels of CCN3 were measured by ELISA. The clinical and laboratory parameters were collected from a clinical record system, and disease activity was determined by joint disease activity score 28 (DAS28). Our results showed that the serum levels of CCN3 were significantly increased in RA patients compared to healthy controls. Furthermore, the CCN3 level was positively correlated with DAS28 (CRP), DAS28 (ESR), and the level of anti-CCP Ab, an autoantibody highly specific for RA. Furthermore, CCN3 showed a positive correlation with inflammatory cytokine IL-6, while no significant correlation with TNF-α was observed. These data suggest that CCN3 plays an important role in the development of RA and might be a potential disease activity biomarker for RA.
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影响因子：
3.7
作者：
Pakradouni J;Le Goff W;Calmel C;Antoine B;Villard E;Frisdal E;Abifadel M;Tordjman J;Poitou C;Bonnefont-Rousselot D;Bittar R;Bruckert E;Clément K;Fève B;Martinerie C;Guérin M
通讯作者：
Guérin M
影响因子：
3.7
作者：
K. Ting;S. Lester;E. Dunstan;C. Hill
通讯作者：
K. Ting;S. Lester;E. Dunstan;C. Hill
影响因子：
25
作者：
Dombrowski Y;O'Hagan T;Dittmer M;Penalva R;Mayoral SR;Bankhead P;Fleville S;Eleftheriadis G;Zhao C;Naughton M;Hassan R;Moffat J;Falconer J;Boyd A;Hamilton P;Allen IV;Kissenpfennig A;Moynagh PN;Evergren E;Perbal B;Williams AC;Ingram RJ;Chan JR;Franklin RJM;Fitzgerald DC
通讯作者：
Fitzgerald DC
影响因子：
4.1
作者：
Peidl A
通讯作者：
Peidl A
影响因子：
4.8
作者：
Lin, CG;Leu, SJ;Lau, LF
通讯作者：
Lau, LF