Induction of human B cell antigens in non-T cell acute lymphoblastic leukemia.
Induction of human B cell antigens in non-T cell acute lymphoblastic leukemia.
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非 T 细胞急性淋巴细胞白血病中人类 B 细胞抗原的诱导。
DOI：
10.1172/jci110633
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Schlossman,SF
中科院分区：
文献类型：
--
作者：
Nadler,LM;Ritz,J;Bates,MP;Park,EK;Anderson,KC;Sallan,SE;Schlossman,SF
来自70% Ia+CALLA+非T细胞急性淋巴细胞白血病（ALL）患者的白血病细胞表达在所有正常B淋巴细胞上发现的抗原（B1）。在这项研究中，研究了不表达B1抗原的ALL细胞，试图进一步阐明这些肿瘤的细胞谱系。使用多种已知可促进细胞分化的药物对非T细胞ALL细胞系和从Ia + CALLA + B1-非T细胞ALL患者中分离的肿瘤细胞进行体外研究。佛波醇二酯（TPA）或植物血凝素条件白细胞培养基能够诱导所有四个非T细胞ALL系的B1的表达。相反，B1不能在相同条件下诱导的早幼粒细胞白血病系或T细胞淋巴母细胞白血病系。随着B1对非T细胞ALL系的诱导，细胞质μ-重链（c μ）变得不可检测，而CALLA和Ia的表达不变。B1的表达伴随着细胞增殖和DNA合成的减少，但未观察到明显的形态学变化。此外，未检测到其他B或T细胞抗原。使用从白血病患者分离的肿瘤细胞进一步研究了非T细胞ALL的细胞起源。8例Ia + CALLA + B1-c mu- ALL患者的肿瘤细胞在TPA的体外诱导下可同时表达B1和c mu。相比之下，来自5名Ia + CALLA-B1-c mu-非T细胞ALL患者的细胞不能用TPA诱导表达CALLA、B1或c mu。这些研究表明，非T细胞ALL是异质性的，代表了一系列早期B细胞分化，包括前前B细胞（Ia + CALLA + B1-c mu-）、中间前B细胞（Ia + CALLA +B1 + c mu-）和最终的“真正”前B细胞（Ia + CALLA + B1 + c mu+）。其余Ia + CALLA-B1-c mu-型非T细胞ALL（20%）的细胞来源仍不清楚。
Leukemic cells from 70% of patients with Ia+CALLA+ non-T cell acute lymphoblastic leukemia (ALL) express an antigen (B1) found on all normal B lymphocytes. In this study, ALL cells that do not express the B1 antigen were studied in an attempt to further elucidate the cellular lineage of these tumors. Non-T cell ALL lines and tumor cells isolated from patients with non-T cell ALL that are Ia + CALLA + B1- were studied in vitro with a variety of agents known to promote cellular differentiation. Phorbol diester (TPA) or phytohemagglutinin conditioned leukocyte culture media were capable of inducing the expression of B1 on all four non-T cell ALL lines tested. In contrast, B1 could not be induced under the identical conditions on a promyelocytic leukemia line or a T cell lymphoblastic leukemia line. With the induction of B1 on non-T cell ALL lines, cytoplasmic mu-heavy chain (c mu) became undetectable, whereas the expression of CALLA and Ia were unchanged. The expression of B1 was accompanied by a decrease of cellular proliferation and DNA synthesis, but not significant morphologic changes were noted. In addition, no other B or T cell antigens were detected. The cellular origin of non-T cell ALL was further investigated using tumor cells isolated from leukemic patients. Tumor cells from eight patients with Ia + CALLA + B1-c mu- ALL could be induced in vitro with TPA to express both B1 and c mu. In contrast, cells from five patients with Ia + CALLA-B1-c mu- non-T cell ALL could not be induced with TPA to express CALLA, B1 or c mu. These studies suggest that the non-T cell ALL are heterogeneous and represent a spectrum of early B cell differentiation including the pre- pre-B cell (Ia + CALLA + B1-c mu-), the intermediate pre-B cell (Ia + CALLA +B1 + c mu-), and finally the "true" pre-B cell (Ia + CALLA + B1 + c mu+). The cellular origin of the remaining Ia + CALLA-B1-c mu- form of non-T cell ALL (20%) is still unknown.
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Ia 样分子在正常和白血病人类细胞表面的分布。
DOI：
--
发表时间：
1976
影响因子：
11.1
作者：
S. Schlossman;L. Chess;R. Humphreys;J. Strominger
通讯作者：
J. Strominger
定义人类血清学上不同的 HLA-D/DR 相关 Ia 样抗原的单克隆抗体。
影响因子：
2.7
作者：
Nadler,LM;Stashenko,P;Hardy,R;Pesando,JM;Yunis,EJ;Schlossman,SF
通讯作者：
Schlossman,SF
影响因子：
4.4
作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
通讯作者：
P. Stashenko;L. Nadler;R. Hardy;S. Schlossman
不同于 B1 的人类 B 细胞特异性抗原 (B2) 的表征。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Nadler,LM;Stashenko,P;Hardy,R;vanAgthoven,A;Terhorst,C;Schlossman,SF
通讯作者：
Schlossman,SF
类似于 B 淋巴细胞前体的白血病细胞中免疫球蛋白表达的多样性
影响因子：
64.8
作者：
L. Vogler;J. Preud’homme;M. Seligmann;W. Gathings;W. Crist;M. Cooper;F. Bollum
通讯作者：
F. Bollum