The Effects of Genetic Relatedness on the Preterm Infant Gut Microbiota.
The Effects of Genetic Relatedness on the Preterm Infant Gut Microbiota.
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遗传相关性对早产儿肠道微生物群的影响。
DOI：
10.3390/microorganisms9020278
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发表时间：
2021-01-29
期刊：
影响因子：
4.5
通讯作者：
Ho T
中科院分区：
文献类型：
--
作者：
Lim SJ;Aguilar-Lopez M;Wetzel C;Dutra SVO;Bray V;Groer MW;Donovan SM;Ho T
早产儿肠道微生物群受环境、内源性、母体和遗传因素的影响。虽然兄弟姐妹具有相似的肠道微生物组成，但尚不清楚遗传亲缘关系如何影响早产儿的α多样性和特定分类群丰度。我们分析了两家新生儿重症监护病房（NICUs）坦帕综合医院（TGH； FL， USA）和卡尔医院（IL， USA）的粪便样本、≤和≤3周龄的16S rRNA基因含量，以及早产多胞胎和单胎的临床数据。牛乳基强化剂（BMF）周数和增重速度是α多样性的显著预测因子。在控制临床因素后，兄弟姐妹之间的α多样性显著相关，特别是在出生后≤3周和TGH NICU。与不相关的个体相比，兄弟姐妹具有更高的肠道微生物组成相似性。在针对临床协变量进行残差处理后，30个常见的操作分类单位在兄弟姐妹之间跨时间点存在相关性。这些细菌属于放线菌门、芽胞杆菌门、拟杆菌门、梭菌门、赤霉菌门和阴性门。除了BMF和体重变量对肠道微生物多样性的影响外，我们的研究还发现了兄弟姐妹之间肠道微生物的相似性，这表明遗传或共同的母亲和环境对早产儿肠道微生物群有影响。
The preterm infant gut microbiota is influenced by environmental, endogenous, maternal, and genetic factors. Although siblings share similar gut microbial composition, it is not known how genetic relatedness affects alpha diversity and specific taxa abundances in preterm infants. We analyzed the 16S rRNA gene content of stool samples, ≤ and >3 weeks postnatal age, and clinical data from preterm multiplets and singletons at two Neonatal Intensive Care Units (NICUs), Tampa General Hospital (TGH; FL, USA) and Carle Hospital (IL, USA). Weeks on bovine milk-based fortifier (BMF) and weight gain velocity were significant predictors of alpha diversity. Alpha diversity between siblings were significantly correlated, particularly at ≤3 weeks postnatal age and in the TGH NICU, after controlling for clinical factors. Siblings shared higher gut microbial composition similarity compared to unrelated individuals. After residualizing against clinical covariates, 30 common operational taxonomic units were correlated between siblings across time points. These belonged to the bacterial classes Actinobacteria, Bacilli, Bacteroidia, Clostridia, Erysipelotrichia, and Negativicutes. Besides the influence of BMF and weight variables on the gut microbial diversity, our study identified gut microbial similarities between siblings that suggest genetic or shared maternal and environmental effects on the preterm infant gut microbiota.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
5.9
作者：
FAITH, DP
通讯作者：
FAITH, DP
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
3.7
作者：
Hewitt KM;Mannino FL;Gonzalez A;Chase JH;Caporaso JG;Knight R;Kelley ST
通讯作者：
Kelley ST
DOI：
10.1097/mpg.0b013e318282a8c2
发表时间：
2013-04-01
影响因子：
2.9
作者：
Gupta, Raegan W.;Lynn Tran;Penn, Duna
通讯作者：
Penn, Duna