Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.
Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.
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DOI：
10.1159/000337370
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发表时间：
2012
影响因子：
2.8
通讯作者：
Johnson JA
中科院分区：
文献类型：
--
作者：
Shafiu M;Johnson RJ;Turner ST;Langaee T;Gong Y;Chapman AB;Gums JG;Johnson JA
高尿酸血症与肥胖和代谢综合征有关。URAT1是一种尿酸盐转运蛋白，我们检测了URAT1转运蛋白基因（SLC22A12）多态性与高血压患者肥胖和代谢综合征的关系。对414例随机对照研究的原发性高血压患者进行SLC22A12 SNPs rs11602903、rs505802和rs11231825基因分型。在高加索人中，SLC22A12 SNP与体重指数（BMI）相关。rs11602903与BMI（p < 0.0001）、腰围（p = 0.003）、HDL胆固醇（p = 0.018）和代谢综合征（p = 0.033）相关，并占白人BMI变异的7%。在非裔美国人中，SLC22A12 SNP rs11602903与BMI，腰围，HDL胆固醇或甘油三酯无关。URAT1基因SLC22A12多态性可能在高加索高血压患者肥胖和代谢综合征中发挥作用。
Hyperuricemia is associated with obesity and the metabolic syndrome. URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects. Patients with essential hypertension (n = 414) from a randomized controlled study were genotyped for SLC22A12 SNPs rs11602903, rs505802 and rs11231825. In Caucasians, SLC22A12 SNPs were associated with the body mass index (BMI). rs11602903 was associated with BMI (p < 0.0001), waist circumference (p = 0.003), HDL cholesterol (p = 0.018) and the metabolic syndrome (p = 0.033), and accounted for 7% of the variation of BMI in Caucasians. In African Americans, SLC22A12 SNP rs11602903 was not associated with BMI, waist circumference, HDL cholesterol or triglycerides. The URAT1 gene SLC22A12 polymorphism may play a role in obesity and the metabolic syndrome in Caucasian hypertensive subjects.
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影响因子：
4.8
作者：
Johnson, Julie A.;Boerwinkle, Eric;Zineh, Issain;Chapman, Arlene B.;Bailey, Kent;Cooper-DeHoff, Rhonda M.;Gums, John;Curry, R. Whit;Gong, Yan;Beitelshees, Amber L.;Schwartz, Gary;Turner, Stephen T.
通讯作者：
Turner, Stephen T.
影响因子：
8.3
作者：
Masuo, K;Kawaguchi, H;Tuck, ML
通讯作者：
Tuck, ML
影响因子：
158.5
作者：
CANNON, PJ;STASON, WB;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
4.8
作者：
Anzai, Naohiko;Ichida, Kimiyoshi;Sakurai, Hiroyuki
通讯作者：
Sakurai, Hiroyuki
影响因子：
13.6
作者：
Reungjui, Sirirat;Roncal, Carlos A.;Nakagawa, Takahiko
通讯作者：
Nakagawa, Takahiko