Age differences in medial prefrontal activity for subsequent memory of truth value.
Age differences in medial prefrontal activity for subsequent memory of truth value.
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DOI：
10.3389/fpsyg.2014.00087
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发表时间：
2014
影响因子：
3.8
通讯作者：
Gutchess AH
中科院分区：
文献类型：
--
作者：
Cassidy BS;Hedden T;Yoon C;Gutchess AH
许多研究表明，与年轻人相比，衰老的标志是源记忆的减少，但一小部分工作表明，增加源信息的社会情感内容可能是减少与年龄相关的表现差异的一种方法。虽然背内侧前额叶皮层（dmPFC）的活动可能支持年轻人和老年人的源记忆，但一个人激活背侧与腹侧mPFC的程度可能反映了一个人与传入信息的个人联系。因为真值可能是一个显着的标记，影响一个人的连接与信息和分配的注意力对传入的材料，我们调查了信息的感知真值是否不同地影响与编码源信息，特别是与年龄相关的mPFC活动的差异。12名年轻人（18-23岁）和12名老年人（63-80岁）编码真实和虚假的陈述。行为结果显示，不同年龄组的记忆力表现相似。关于与随后的记忆相关的神经活动，年轻人，相对于老年人，表现出更大的活动，在dmPFC，而老年人显示增强腹内侧前额叶皮层（vmPFC）和颞叶参与相对年轻。这些结果可能表明，年轻人专注于一般知识获取目标，而老年人则专注于材料的情感相关方面。研究结果表明，与编码源信息相关的mPFC招募的年龄相关差异可能在某些情况下是年龄等效的行为表现的基础。
Much research has demonstrated that aging is marked by decreased source memory relative to young adults, yet a smaller body of work has demonstrated that increasing the socioemotional content of source information may be one way to reduce age-related performance differences. Although dorsomedial prefrontal cortex (dmPFC) activity may support source memory among young and older adults, the extent to which one activates dorsal vs. ventral mPFC may reflect one's personal connection with incoming information. Because truth value may be one salient marker that impacts one's connection with information and allocation of attention toward incoming material, we investigated whether the perceived truth value of information differently impacts differences in mPFC activity associated with encoding source information, particularly with age. Twelve young (18–23 years) and 12 older adults (63–80 years) encoded true and false statements. Behavioral results showed similar memory performance between the age groups. With respect to neural activity associated with subsequent memory, young adults, relative to older adults, exhibited greater activity in dmPFC while older adults displayed enhanced ventromedial prefrontal cortex (vmPFC) and insula engagement relative to young. These results may potentially indicate that young adults focus on a general knowledge acquisition goal, while older adults focus on emotionally relevant aspects of the material. The findings demonstrate that age-related differences in recruitment of mPFC associated with encoding source information may in some circumstances underlie age-equivalent behavioral performance.
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