Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan.
Histopathological Characterization of Cases of Spontaneous Fatal Feline Severe Fever with Thrombocytopenia Syndrome, Japan.
复制标题
DOI：
10.3201/eid2704.204148
复制
发表时间：
2021-04
影响因子：
11.8
通讯作者：
Maeda K
中科院分区：
文献类型：
--
作者：
Sakai Y;Kuwabara Y;Ishijima K;Kagimoto S;Mura S;Tatemoto K;Kuwata R;Yonemitsu K;Minami S;Kuroda Y;Baba K;Okuda M;Shimoda H;Sakurai M;Morimoto M;Maeda K
严重发热伴血小板减少综合征（SFTS）是由SFTS病毒（SFTSV）引起的一种新型蜱传传染病。我们报告了7例自发性致命的SFTS猫。尸检发现特征性病变，包括5例坏死性淋巴结炎和所有病例的坏死性脾炎和SFTSV阳性母细胞淋巴细胞。我们在6例胃肠道和3例肺中检测到出血性病变，表明猫科动物的SFTS临床病程比人类更严重。3例胃肠道、2例肺、4例肝出现坏死或溃疡灶。我们阐明了母细胞淋巴细胞是SFTSV的主要靶细胞，并参与诱导坏死灶。我们还发现胸腺上皮细胞是SFTSV的额外靶点。这些结果为病理检查期间诊断猫SFTS提供了见解，并证明了猫和人SFTS病例的相似性。
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease caused by SFTS virus (SFTSV). We report 7 cases of spontaneous fatal SFTS in felines. Necropsies revealed characteristic lesions, including necrotizing lymphadenitis in 5 cases and necrotizing splenitis and SFTSV-positive blastic lymphocytes in all cases. We detected hemorrhagic lesions in the gastrointestinal tract in 6 cases and lungs in 3 cases, suggesting a more severe clinical course of SFTS in felids than in humans. We noted necrotic or ulcerative foci in the gastrointestinal tract in 3 cases, the lung in 2 cases, and the liver in 4 cases. We clarified that blastic lymphocytes are predominant targets of SFTSV and involved in induction of necrotic foci. We also found that thymic epithelial cells were additional targets of SFTSV. These results provide insights for diagnosing feline SFTS during pathological examination and demonstrate the similarity of feline and human SFTS cases.
登录
查看更多内容
影响因子：
2.2
作者：
Hiraki T;Yoshimitsu M;Suzuki T;Goto Y;Higashi M;Yokoyama S;Tabuchi T;Futatsuki T;Nakamura K;Hasegawa H;Saijo M;Kakihana Y;Arima N;Yonezawa S
通讯作者：
Yonezawa S
影响因子：
6.4
作者：
Jin, Cong;Jiang, Hong;Li, Dexin
通讯作者：
Li, Dexin
中国一种新型布尼亚病毒引起的发热伴血小板减少症。
DOI：
10.1056/nejmoa1010095
发表时间：
2011-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Yu XJ;Liang MF;Zhang SY;Liu Y;Li JD;Sun YL;Zhang L;Zhang QF;Popov VL;Li C;Qu J;Li Q;Zhang YP;Hai R;Wu W;Wang Q;Zhan FX;Wang XJ;Kan B;Wang SW;Wan KL;Jing HQ;Lu JX;Yin WW;Zhou H;Guan XH;Liu JF;Bi ZQ;Liu GH;Ren J;Wang H;Zhao Z;Song JD;He JR;Wan T;Zhang JS;Fu XP;Sun LN;Dong XP;Feng ZJ;Yang WZ;Hong T;Zhang Y;Walker DH;Wang Y;Li DX
通讯作者：
Li DX
影响因子：
3.3
作者：
Matsuu, Aya;Momoi, Yasuyuki;Maeda, Ken
通讯作者：
Maeda, Ken
影响因子：
2.2
作者：
Kaneyuki, Shozo;Yoshikawa, Tomoki;Saijo, Masayuki
通讯作者：
Saijo, Masayuki