Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA).
Consensus on Shared Measures of Mobility and Cognition: From the Canadian Consortium on Neurodegeneration in Aging (CCNA).
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DOI：
10.1093/gerona/gly148
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发表时间：
2019-05-16
期刊：
影响因子：
--
通讯作者：
Canadian Gait and Cognition Network
中科院分区：
文献类型：
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作者：
Montero-Odasso M;Almeida QJ;Bherer L;Burhan AM;Camicioli R;Doyon J;Fraser S;Muir-Hunter S;Li KZH;Liu-Ambrose T;McIlroy W;Middleton L;Morais JA;Sakurai R;Speechley M;Vasudev A;Beauchet O;Hausdorff JM;Rosano C;Studenski S;Verghese J;Canadian Gait and Cognition Network
一种新的模式正在出现，即以前在老年人中分别研究、诊断和管理的行动能力和认知障碍，实际上是由共享的大脑资源调节的。正常的衰老和神经退行性变导致这些共同的大脑机制恶化，增加了患痴呆、跌倒和骨折的风险。这种新的范例需要一种综合的方法来度量这两个领域。我们的目标是在社区居住的老年人中确定一套现有的活动能力和认知能力测试的补充系统，以评估运动-认知相互作用。老年人活动能力和认知方面的专家参与了基于德尔菲过程的半结构化共识。在进行范围审查以选择候选测试之后，多轮磋商提供了关于捕获移动性和认知共同特征的测试的结构化反馈。这些测试需要对活动能力和认知能力的变化敏感，适用于所有研究和诊所，对干预措施敏感，在老年人中可行，先前已经过验证，并且具有最小的上限/下限效应。在评估的17项试验中，有10项试验符合预先规定的标准，并被选为试验“核心系列”的一部分。专家小组还建议进行“最小电池”测试，包括步态速度、双任务步态速度、蒙特利尔认知评估和轨迹制造测试A&B。一套标准化的评估系统能够捕捉到衰老和神经退行性疾病中移动性和认知的共同特征，这可能会增加研究之间的可比性，发现微妙或常见的可逆因素，并加速痴呆、跌倒和衰老相关残疾的研究进展。
A new paradigm is emerging in which mobility and cognitive impairments, previously studied, diagnosed, and managed separately in older adults, are in fact regulated by shared brain resources. Deterioration in these shared brain mechanisms by normal aging and neurodegeneration increases the risk of developing dementia, falls, and fractures. This new paradigm requires an integrated approach to measuring both domains. We aim to identify a complementary battery of existing tests of mobility and cognition in community-dwelling older adults that enable assessment of motor-cognitive interactions. Experts on mobility and cognition in aging participated in a semistructured consensus based on the Delphi process. After performing a scoping review to select candidate tests, multiple rounds of consultations provided structured feedback on tests that captured shared characteristics of mobility and cognition. These tests needed to be sensitive to changes in both mobility and cognition, applicable across research studies and clinics, sensitive to interventions, feasible to perform in older adults, been previously validated, and have minimal ceiling/floor effects. From 17 tests appraised, 10 tests fulfilled prespecified criteria and were selected as part of the “Core-battery” of tests. The expert panel also recommended a “Minimum-battery” of tests that included gait speed, dual-task gait speed, the Montreal Cognitive Assessment and Trail Making Test A&B. A standardized assessment battery that captures shared characteristics of mobility and cognition seen in aging and neurodegeneration may increase comparability across research studies, detection of subtle or common reversible factors, and accelerate research progress in dementia, falls, and aging-related disabilities.
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影响因子：
5.5
作者：
Clouston SA;Brewster P;Kuh D;Richards M;Cooper R;Hardy R;Rubin MS;Hofer SM
通讯作者：
Hofer SM
影响因子：
10.6
作者：
ALEXOPOULOS, GS;ABRAMS, RC;SHAMOIAN, CA
通讯作者：
SHAMOIAN, CA
DOI：
10.1093/gerona/glv092
发表时间：
2016-03-01
影响因子：
5.1
作者：
Allali, Gilles;Ayers, Emmeline I.;Verghese, Joe
通讯作者：
Verghese, Joe
影响因子：
5.1
作者：
Allali G;Annweiler C;Blumen HM;Callisaya ML;De Cock AM;Kressig RW;Srikanth V;Steinmetz JP;Verghese J;Beauchet O
通讯作者：
Beauchet O
DOI：
10.1249/mss.0b013e31806ad708
发表时间：
2007-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Bixby, Walter R.;Spalding, Thomas W.;Hatfield, Bradley D.
通讯作者：
Hatfield, Bradley D.