Enhancers and silencers: an integrated and simple model for their function.
Enhancers and silencers: an integrated and simple model for their function.
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DOI:
10.1186/1756-8935-5-1
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发表时间:
2012-01-09
影响因子:
3.9
通讯作者:
Papantonis A
中科院分区:
文献类型:
--
作者:
Kolovos P;Knoch TA;Grosveld FG;Cook PR;Papantonis A
Regulatory DNA elements such as enhancers, silencers and insulators are embedded in metazoan genomes, and they control gene expression during development. Although they fulfil different roles, they share specific properties. Herein we discuss some examples and a parsimonious model for their function is proposed. All are transcription units that tether their target promoters close to, or distant from, transcriptional hot spots (or 'factories').
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