Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect.
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DOI:
10.1007/s00702-011-0747-x
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发表时间:
2012-06
影响因子:
3.3
通讯作者:
Phan, K. Luan
中科院分区:
文献类型:
--
作者:
Rabinak, Christine A.;Sripada, Chandra Sekhar;Angstadt, Mike;de Wit, Harriet;Phan, K. Luan
Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of Δ9-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.
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