Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study.
Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study.
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DOI：
10.1007/s00125-012-2633-y
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发表时间：
2012-10
期刊：
影响因子：
8.2
通讯作者：
Pischon, T.
中科院分区：
文献类型：
--
作者：
Montonen, J.;Boeing, H.;Steffen, A.;Lehmann, R.;Fritsche, A.;Joost, H. -G.;Schulze, M. B.;Pischon, T.
这项研究的目的是前瞻性地检查体内铁储存与2型糖尿病风险之间的关系。在基于人群的欧洲癌症与营养前瞻性研究(EPIC)-波茨坦研究中，我们设计了一项病例队列研究，对象为27,548人。在7年的随访中，发现了849例2型糖尿病病例。在排除了数据缺失或基线血糖水平异常的参与者后，607人留下来进行分析。在应用相同的排除标准后，从整个队列中随机选择了2,500人的子队列，包括1,969人。在调整了年龄、性别、体重指数、腰围、运动、骑自行车、教育、职业活动、吸烟习惯、饮酒和循环γ-谷氨酰转移酶、丙氨酸氨基转移酶、胎球蛋白-A、超敏C-反应蛋白、脂联素、高密度脂蛋白-胆固醇和三酰甘油水平后，血清铁蛋白浓度越高，患2型糖尿病的风险越高(最高的五分位数的RR为1.73；95%可信区间为1.15，2.61；p趋势 = 为0.002)。未观察到可溶性转铁蛋白受体的显著相关性(RR1.33；95%CI0.85，2.09；p趋势 = 0.50)。可溶性转铁蛋白受体/铁蛋白比值与风险呈显著负相关(RR0.61；95%CI 0.41，0.91；p趋势 = 0.02)。高铁蛋白水平与2型糖尿病的高风险相关，独立于已确立的糖尿病危险因素和一系列糖尿病生物标志物，而可溶性转铁蛋白受体浓度与风险无关。这些结果支持这样一种假设，即较高的铁储存水平低于血色素沉着症水平与患2型糖尿病的风险有关。
The aim of this study was to prospectively examine the association between body iron stores and risk of type 2 diabetes. We designed a case–cohort study among 27,548 individuals within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. During 7 years of follow-up, 849 incident cases of type 2 diabetes were identified. Of these, 607 remained for analyses after exclusion of participants with missing data or abnormal glucose levels at baseline. A sub-cohort of 2,500 individuals was randomly selected from the full cohort, comprising 1,969 individuals after applying the same exclusion criteria. After adjustment for age, sex, BMI, waist circumference, sports activity, bicycling, education, occupational activity, smoking habit, alcohol consumption and circulating levels of γ-glutamyltransferase, alanine aminotransferase, fetuin-A, high-sensitivity C-reactive protein, adiponectin, HDL-cholesterol and triacylglycerol, higher serum ferritin concentrations were associated with a higher risk of type 2 diabetes (RR in the highest vs lowest quintile, 1.73; 95% CI 1.15, 2.61; p trend = 0.002). No significant association was observed for soluble transferrin receptor (RR 1.33; 95% CI 0.85, 2.09; p trend = 0.50). The soluble transferrin receptor-to-ferritin ratio was significantly inversely related to risk (RR 0.61; 95% CI 0.41, 0.91; p trend = 0.02). High ferritin levels are associated with higher risk of type 2 diabetes independently of established diabetes risk factors and a range of diabetes biomarkers whereas soluble transferrin receptor concentrations are not related to risk. These results support the hypothesis that higher iron stores below the level of haemochromatosis are associated with risk of type 2 diabetes.
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通讯作者：
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