Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging.
Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging.
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DOI：
10.1016/j.jacc.2009.03.033
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发表时间：
2009-06-23
影响因子：
24
通讯作者：
Floyd, Thomas F.
中科院分区：
文献类型：
--
作者：
Wu, Wen-Chau;Mohler, Emile;Ratcliffe, Sarah J.;Wehrli, Felix W.;Detre, John A.;Floyd, Thomas F.
我们介绍了连续动脉自旋标记(CASL)磁共振成像(MRI)在进行性外周动脉疾病(PAD)受试者中测量小腿肌肉血流灌注的新应用。PAD主要被认为是一种导管血管疾病。PAD对终末器官肌肉微血管血流的影响尚不清楚。CASL是一种能够测量微血管血流的无创性MRI方法，有助于我们了解PAD对微血管系统的影响。40名不同程度的PAD患者和17名年龄匹配的无PAD患者接受了踝臂指数(ABI)和CASL的测量。计算和评估峰值充血流量(PHF)和达峰时间(TTP)作为ABI和小腿肌群的函数。Ph F(p=0.0 4)和TTP(p<；10−4)均存在ABI依赖。虽然TTP对增加的PAD严重程度几乎立即有反应，但PHF一直保存到受试者陷入2级目录，甚至在比目鱼肌中保存更长时间。CASL血流测量与ABI测量的疾病状态相关，也显示了在存在早期到中期血管疾病时保留的微血管血流储备。
We present the novel application of continuous arterial spin-labeling (CASL) magnetic resonance imaging (MRI) for the measurement of calf muscle perfusion in subjects with progressive peripheral arterial disease (PAD). PAD is largely considered to be a disease of conduit vessels. The impact of PAD upon microvascular flow in the end-organ, muscle, remains unknown. CASL is a noninvasive MRI method capable of measuring microvascular flow and may assist in our understanding of the impact of PAD upon the microvasculature. Forty subjects with varying degrees of PAD and seventeen age-matched PAD-free subjects were recruited and underwent measurement of the ankle-to-brachial index (ABI) and CASL. Peak hyperemic flow (PHF) and time-to-peak (TTP) were computed and assessed as a function of ABI and calf muscle group. ABI dependence was found in both PHF (p = 0.04) and TTP (p < 10−4). While TTP responded almost immediately to increasing PAD severity, PHF was preserved until subjects fell into cateogory-2 and even longer in the soleus muscle. CASL flow measurements correlate with disease state as measured by ABI, and also demonstrate preserved microvascular flow reserve in the presence of early to intermediate vascular disease.
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DOI：
10.1073/pnas.91.1.33
发表时间：
1994-01-04
影响因子：
11.1
作者：
ROBERTS, DA;DETRE, JA;LEIGH, JS
通讯作者：
LEIGH, JS
DOI：
10.1152/ajpheart.01399.2007
发表时间：
2008-05-01
影响因子：
4.8
作者：
Wu, Wen-Chau;Wang, Jiongjiong;Floyd, Thomas F.
通讯作者：
Floyd, Thomas F.
影响因子：
4.4
作者：
Wu, Wen-Chau;Wang, Jiongjiong;Detre, John A.;Ratcliffe, Sarah J.;Floyd, Thomas F.
通讯作者：
Floyd, Thomas F.
影响因子：
3.3
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者：
KORETSKY, AP
DOI：
10.1097/00004647-199611000-00019
发表时间：
1996-11-01
影响因子：
6.3
作者：
Alsop, DC;Detre, JA
通讯作者：
Detre, JA