Association between Visceral Adipose Tissue and Non-Alcoholic Steatohepatitis Histology in Patients with Known or Suspected Non-Alcoholic Fatty Liver Disease.
Association between Visceral Adipose Tissue and Non-Alcoholic Steatohepatitis Histology in Patients with Known or Suspected Non-Alcoholic Fatty Liver Disease.
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DOI：
10.3390/jcm10122565
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发表时间：
2021-06-10
影响因子：
3.9
通讯作者：
Venkatesh SK
中科院分区：
文献类型：
--
作者：
Idilman IS;Low HM;Gidener T;Philbrick K;Mounajjed T;Li J;Allen AM;Yin M;Venkatesh SK
(1)目的：探讨核磁共振成像(MRI)测定内脏脂肪组织(VAT)和质子密度脂肪分数(PDFF)与已知或疑似非酒精性脂肪性肝病(NAFLD)患者的肝脏脂肪变性(HS)、非酒精性脂肪性肝炎(NASH)和肝纤维化(HF)的关系。(2)方法：135名在MRI检查后3个月(肥胖队列)或1个月(NAFLD队列)内接受肝活检的受试者为研究组。VAT体积在L2-L3水平通过基于信号强度的绘制在反相图像上使用半定量软件进行量化。在脂肪分数图上计算肝脏PDFF和胰腺PDFF。肝脏体积(LVOL)和脾体积(SVOL)也使用PACS上提供的半自动3D体积工具进行计算。组织学分析是由一位对影像发现视而不见的肝病专家进行的。(3)研究人群的LVOL、SVOL、肝脏PDFF值、胰腺PDFF值和VAT的平均值分别为2492.2、381.6、13.2%、12.7%和120.6毫升。VAT与肝脏PDF值呈中度相关(r=0.41p<；0.001)，与LVOL(r=0.38p<；0.001)、SVOL(r=0.20p=0.025)和胰腺PDF值(rs0.29，p=0.001)呈弱相关。HS(p<；0.001)、NASH(p<；005)和HF(p<；005)患者的VAT、LVOL和肝脏PDFF值均显著升高。小叶性炎症(p=0.019)和肝细胞气肿(p=0.001)时VAT也显著升高。预测HS、NASH和HF的VAT临界值分别为101.8、111.8和111.6毫升。(4)结论：MRI测定的VAT可用于预测已知或可疑NAFLD患者是否存在HS、NASH和HF。
(1) Purpose: To determine the association between visceral adipose tissue (VAT) and proton density fat fraction (PDFF) with magnetic resonance imaging (MRI), and hepatic steatosis (HS), non-alcoholic steatohepatitis (NASH) and hepatic fibrosis (HF) in patients with known or suspected non-alcoholic fatty liver disease (NAFLD). (2) Methods: 135 subjects that had a liver biopsy performed within 3 months (bariatric cohort) or 1 month (NAFLD cohort) of an MRI exam formed the study group. VAT volume was quantified at L2-L3 level on opposed-phase images with signal intensity-based painting using a semi-quantitative software. Liver PDFF and pancreas PDFF were calculated on fat fraction maps. Liver volume (Lvol) and spleen volume (Svol) were also calculated using a semi-automated 3D volume tool available on PACS. A histological analysis was performed by an expert hepatopathologist blinded to imaging findings. (3) Results: The mean Lvol, Svol, liver PDFF, pancreas PDFF and VAT of the study population were 2492.2 mL, 381.6 mL, 13.2%, 12.7% and 120.6 mL, respectively. VAT showed moderate correlation with liver PDFF (r = 0.41, p < 0.001) and weak correlation with Lvol (r = 0.38, p < 0.001), Svol (r = 0.20, p = 0.025) and pancreas PDFF (rs = 0.29, p = 0.001). VAT, Lvol and liver PDFF were significantly higher in patients with HS (p < 0.001), NASH (p < 0.05) and HF (p < 0.05). VAT was also significantly higher in the presence of lobular inflammation (p = 0.019) and hepatocyte ballooning (p = 0.001). The cut-off VAT volumes for predicting HS, NASH and HF were 101.8 mL (AUC, 0.7), 111.8 mL (AUC, 0.64) and 111.6 mL (AUC, 0.66), respectively. (4) Conclusion: The MRI determined VAT can be used for predicting the presence of HS, NASH and HF in patients with known or suspected NAFLD.
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影响因子：
4.8
作者：
Yu AH;Duan-Mu YY;Zhang Y;Wang L;Guo Z;Yu YQ;Wang YS;Cheng XG
通讯作者：
Cheng XG
影响因子：
19.7
作者：
Kuehn, Jens-Peter;Berthold, Friederike;Meffert, Peter J.
通讯作者：
Meffert, Peter J.
影响因子：
5.5
作者：
Jakobsen, M. U.;Berentzen, T.;Overvad, K.
通讯作者：
Overvad, K.
影响因子：
29.4
作者：
Matteoni, CA;Younossi, ZM;McCullough, AJ
通讯作者：
McCullough, AJ
影响因子：
19.7
作者：
Tang, An;Desai, Ajinkya;Sirlin, Claude B.
通讯作者：
Sirlin, Claude B.