Correlation between Non-Alcoholic Fatty Liver Disease and Visceral Adipose Tissue in Non-Obese Chinese Adults: A CT Evaluation.
Correlation between Non-Alcoholic Fatty Liver Disease and Visceral Adipose Tissue in Non-Obese Chinese Adults: A CT Evaluation.
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DOI：
10.3348/kjr.2018.19.5.923
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发表时间：
2018-09
影响因子：
4.8
通讯作者：
Cheng XG
中科院分区：
文献类型：
--
作者：
Yu AH;Duan-Mu YY;Zhang Y;Wang L;Guo Z;Yu YQ;Wang YS;Cheng XG
利用计算机断层扫描（CT）研究非肥胖中国成年人非酒精性脂肪性肝病与内脏脂肪组织的相关性。该研究包括454名接受腹部CT扫描的受试者。根据肝实质衰减值（CTLP）、肝脾衰减比（LSratio）、肝脾衰减差（LSdif） 3项指标评价肝脾CT衰减程度及肝脏脂肪浸润程度。测定大鼠L2/3和L4/5水平的内脏脂肪面积（VFA）和总脂肪面积（TFA），计算腹腔皮下脂肪面积（SFA）。采用双变量相关分析确定各因素之间的相关性。在男性中，L2/3和L4/5水平的VFA、SFA和TFA在区分脂肪肝和非脂肪肝的三项指标上有显著性差异（均p < 0.001）。在男性中，这三项指标均与TFA、SFA和VFA呈负相关（均p < 0.001）。3个指标与VFA在L2/3水平的负相关高于L4/5水平（CTLP为r = - 0.476比- 0.340，LSratio为r = - 0.502比r = - 0.413， LSdif为r = - 0.543比r = - 0.422, p < 0.001）。L2/3和L4/5水平上LSratio、LSdif与VFA的负相关高于相应水平上的SFA。在女性中，3项指标与L2/3、L4/5水平的VFA、TFA均呈负相关，且CTLP与VFA的负相关性在L2/3水平高于L4/5水平（r = - 0.294 vs r = - 0.254, p < 0.001）。在非肥胖的中国成年人中，肝脏脂肪浸润程度与腹部脂肪在CT上表现出很强的相关性。与L4/5水平的VFA相比，L2/3水平的VFA与脂肪肝的关系更为密切。
To investigate the correlation between non-alcoholic fatty liver disease and visceral adipose tissue in non-obese Chinese adults using computed tomography (CT). The study included 454 subjects undergoing abdominal CT scan. Degree of CT attenuation in liver and spleen, and the degree of fat infiltration in liver were evaluated according to three indices: the attenuation value of liver parenchyma (CTLP), the attenuation ratio of liver and spleen (LSratio) and the attenuation difference between liver and spleen (LSdif). Visceral fat area (VFA) and total fat area (TFA) at L2/3 and L4/5 levels were measured, and the abdominal subcutaneous fat area (SFA) was calculated. Bivariate correlation analysis was carried out to determine the correlation among these factors. In men, VFA, SFA and TFA at L2/3 and L4/5 levels showed significant differences in terms of the three indices to distinguish fatty liver from non-fatty liver (all, p < 0.001). In men, all the three indices showed negative correlation with TFA, SFA and VFA (all, p < 0.001). The negative correlation between the three indices and VFA at the L2/3 level was higher than at L4/5 level (r = −0.476 vs. r = −0.340 for CTLP, r = −0.502 vs. r = −0.413 for LSratio, r = −0.543 vs. r = −0.422 for LSdif, p < 0.001, respectively). The negative correlation between LSratio, LSdif and VFA at L2/3 and L4/5 levels was higher than SFA at the corresponding level. In women, all the three indices showed negative correlation with VFA and TFA at L2/3 and L4/5 levels, and the negative correlation between CTLP and VFA was higher at L2/3 level than at L4/5 level (r = −0.294 vs. r = −0.254, p < 0.001). In non-obese Chinese adults, the degree of hepatic fatty infiltration showed a strong correlation with abdominal fat on CT. VFA at L2/3 level was more closely related to fatty liver compared with VFA at L4/5 level.
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