Positive selection on mitochondria may eliminate heritable microbes from arthropod populations.
Positive selection on mitochondria may eliminate heritable microbes from arthropod populations.
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DOI：
10.1098/rspb.2021.1735
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发表时间：
2021-09-29
期刊：
影响因子：
--
通讯作者：
Hurst GDD
中科院分区：
文献类型：
--
作者：
Fenton A;Camus MF;Hurst GDD
不同的真核生物类群携带兼性的可遗传共生体，即从母亲传给后代的微生物。这些共生体与线粒体是共遗传的，选择新的共生体或新的共生体变体，已知会导致线粒体多样性的丧失，作为一种相关的反应。最近，关于线粒体间歇性定向选择的证据已经积累，但对共生体进化的影响目前尚不清楚。因此，我们采用了群体遗传平均场框架来模拟三种常见的宿主-共生体相互作用场景下线粒体DNA(MtDNA)选择对共生体频率的影响。我们的模型预测，对mtDNA的直接选择可以将共生体赶出种群，其中肯定选择的mtDNA突变最初发生在没有感染共生体的个体中，并且共生体最初的频率很低。相反，当阳性选择的线粒体DNA突变发生在共生菌感染的个体中时，突变变得固定，这样做就从种群中消除了共生菌的变异。我们的结论是，以前从共生体选择的角度来看待共生体和线粒体的分子进化推动了中性mtDNA标记的进化，应该根据mtDNA的正选择来重新评估共生体和线粒体的分子进化。
Diverse eukaryotic taxa carry facultative heritable symbionts, microbes that are passed from mother to offspring. These symbionts are coinherited with mitochondria, and selection favouring either new symbionts, or new symbiont variants, is known to drive loss of mitochondrial diversity as a correlated response. More recently, evidence has accumulated of episodic directional selection on mitochondria, but with currently unknown consequences for symbiont evolution. We therefore employed a population genetic mean field framework to model the impact of selection on mitochondrial DNA (mtDNA) upon symbiont frequency for three generic scenarios of host–symbiont interaction. Our models predict that direct selection on mtDNA can drive symbionts out of the population where a positively selected mtDNA mutation occurs initially in an individual that is uninfected with the symbiont, and the symbiont is initially at low frequency. When, by contrast, the positively selected mtDNA mutation occurs in a symbiont-infected individual, the mutation becomes fixed and in doing so removes symbiont variation from the population. We conclude that the molecular evolution of symbionts and mitochondria, which has previously been viewed from a perspective of selection on symbionts driving the evolution of a neutral mtDNA marker, should be reappraised in the light of positive selection on mtDNA.
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影响因子：
9.8
作者：
Hornett EA;Charlat S;Duplouy AM;Davies N;Roderick GK;Wedell N;Hurst GD
通讯作者：
Hurst GD
影响因子：
6.7
作者：
Kriesner P;Hoffmann AA;Lee SF;Turelli M;Weeks AR
通讯作者：
Weeks AR
DOI：
10.1111/j.1095-8312.1996.tb01446.x
发表时间：
1996-08-01
影响因子：
1.9
作者：
Johnstone, RA;Hurst, GDD
通讯作者：
Hurst, GDD
影响因子：
3
作者：
Heyworth, Eleanor R.;Smee, Melanie R.;Ferrari, Julia
通讯作者：
Ferrari, Julia
影响因子：
1.5
作者：
Charlesworth, B
通讯作者：
Charlesworth, B