Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.
Cutting edge: mast cells critically augment myeloid-derived suppressor cell activity.
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DOI：
10.4049/jimmunol.1200647
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发表时间：
2012-07-15
期刊：
影响因子：
--
通讯作者：
Conrad DH
中科院分区：
文献类型：
--
作者：
Saleem SJ;Martin RK;Morales JK;Sturgill JL;Gibb DR;Graham L;Bear HD;Manjili MH;Ryan JJ;Conrad DH
Myeloid derived suppressor cells (MDSCs) are primarily recognized for their immunosuppressive properties in malignant disease. However, their interaction with other innate immune cells and their regulation of immune responses such as in parasitic infection necessitate further characterization. We utilized our previously published mouse model of MDSC accumulation to examine the immunoregulatory role of MDSCs in B16 melanoma metastasis and Nippostrongylus brasiliensis (Nb) infection. Here we demonstrate that the activity of MDSCs is dependent on the immune stimuli and subset induced. Monocytic MDSCs predictably suppressed anti-tumor immune responses but granulocytic MDSCs surprisingly enhanced the clearance of Nb infection. Intriguingly, both results were dependent on MDSC interaction with mast cells (MCs) as demonstrated by adoptive transfer studies in MC-deficient (KitWsh/Wsh) mice. These findings were further supported by ex vivo co-cultures of MCs and MDSCs, indicating a synergistic increase in cytokine production. Thus MCs can enhance both immunosuppressive and immunosupportive functions of MDSCs.
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影响因子：
1.2
作者：
Narita, Yoshinori;Wakita, Daiko;Nishimura, Takashi
通讯作者：
Nishimura, Takashi
影响因子：
1.8
作者：
Miller, HRP
通讯作者：
Miller, HRP
影响因子：
4.4
作者：
Oldford, Sharon A.;Haidl, Ian D.;Marshall, Jean S.
通讯作者：
Marshall, Jean S.
影响因子：
--
作者：
Camberis, Mali;Le Gros, Graham;Urban, Joseph Jr
通讯作者：
Urban, Joseph Jr
DOI：
10.4049/jimmunol.0804253
发表时间：
2009-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hanson EM;Clements VK;Sinha P;Ilkovitch D;Ostrand-Rosenberg S
通讯作者：
Ostrand-Rosenberg S