Can the human lumbar posterior columns be stimulated by transcutaneous spinal cord stimulation? A modeling study.
Can the human lumbar posterior columns be stimulated by transcutaneous spinal cord stimulation? A modeling study.
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DOI：
10.1111/j.1525-1594.2011.01213.x
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发表时间：
2011-03
影响因子：
2.4
通讯作者：
Minassian K
中科院分区：
文献类型：
--
作者：
Danner SM;Hofstoetter US;Ladenbauer J;Rattay F;Minassian K
刺激人类不同的脊髓节段是一种广泛发展的临床实践，用于改变疼痛，改变感觉和运动。人腰椎已成为硬膜外和经皮脊髓刺激改良运动控制的靶点。腰椎后柱代表一个垂直的轴突系统，当被激活时，可以增加脊髓运动控制的其他输入，而不是刺激后根。我们使用详细的躯干三维体积导体模型和McIntyre-Richard-Grill轴突模型来计算经皮腰椎脊髓刺激后柱内轴突的阈值。位于表层的大直径后柱多侧枝纤维的阈值为45.4 V，是后根纤维（14.1 V）的3倍。在激活后柱轴突所需的刺激强度下，大小直径的后根纤维和前根纤维被共同激活。当对腰椎后部结构施加超过大直径后根纤维阈值强度的刺激时，报告的结果揭示了这些阈值差异。
Stimulation of different spinal cord segments in humans is a widely developed clinical practice for modification of pain, altered sensation and movement. The human lumbar cord has become a target for modification of motor control by epidural and more recently by transcutaneous spinal cord stimulation. Posterior columns of the lumbar spinal cord represent a vertical system of axons and when activated can add other inputs to the motor control of the spinal cord than stimulated posterior roots. We used a detailed three-dimensional volume conductor model of the torso and the McIntyre-Richard-Grill axon model to calculate the thresholds of axons within the posterior columns in response to transcutaneous lumbar spinal cord stimulation. Superficially located large diameter posterior column fibers with multiple collaterals have a threshold of 45.4 V, three times higher than posterior root fibers (14.1 V). With the stimulation strength needed to activate posterior column axons, posterior root fibers of large and small diameters as well as anterior root fibers are co-activated. The reported results inform on these threshold differences, when stimulation is applied to the posterior structures of the lumbar cord at intensities above the threshold of large-diameter posterior root fibers.
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影响因子：
2.5
作者：
Lloyd, DPC
通讯作者：
Lloyd, DPC
影响因子：
4.6
作者：
STRUIJK, JJ;HOLSHEIMER, J;BOOM, HBK
通讯作者：
BOOM, HBK
影响因子：
3.2
作者：
Kuhn, Andreas;Keller, Thierry;Morari, Manfred
通讯作者：
Morari, Manfred
影响因子：
7.7
作者：
Barolat, G
通讯作者：
Barolat, G
DOI：
10.1111/j.1749-6632.1998.tb09062.x
发表时间：
1998-01-01
期刊：
NEURONAL MECHANISMS FOR GENERATING LOCOMOTOR ACTIVITY
影响因子：
--
作者：
Dimitrijevic, MR;Gerasimenko, Y;Pinter, MM
通讯作者：
Pinter, MM