Toxoplasmosis Titers and past Suicide Attempts Among Older Adolescents Initiating SSRI Treatment.
Toxoplasmosis Titers and past Suicide Attempts Among Older Adolescents Initiating SSRI Treatment.
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DOI：
10.1080/13811118.2016.1158677
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Calarge C
中科院分区：
文献类型：
--
作者：
Coryell W;Yolken R;Butcher B;Burns T;Dindo L;Schlechte J;Calarge C
弓形虫病潜伏感染是一种普遍的疾病，在动物研究中与高危行为有关，在人类研究中与自杀和自杀企图有关。本分析调查了最近开始使用SSRI治疗的一组年龄较大的青少年的自杀企图史和弓形虫病滴度之间的关系。在108名参与者中，17名（15.7%）有至少一次自杀未遂史。所有人都接受了结构化和非结构化的诊断访谈，并提供了血液样本。2人（11.9%）有自杀史，2人（2.1%）无自杀史，弓形虫滴度≥10 IU/ml （p = 0.166）。有自杀史的患者的平均弓形虫病滴度与没有自杀史的患者有显著差异（p = 0.018）。ROC分析表明，与通常用于鉴定血清阳性的阈值相比，区分有和没有自杀企图的患者的最佳阈值（3.6 IU/ml）较低。弓形虫滴度可以量化接受抗抑郁药物治疗的年轻人的自杀倾向。
Latent infection with toxoplasmosis is a prevalent condition that has been linked in animal studies to high-risk behaviors, and in humans, to suicide and suicide attempts. This analysis investigated a relationship between suicide attempt history and toxoplasmosis titers in a group of older adolescents who had recently begun treatment with an SSRI. Of 108 participants, 17 (15.7 %) had a lifetime history of at least one suicide attempt. All were given structured and unstructured diagnostic interviews and provided blood samples. Two individuals (11.9%) with a past suicide attempt, and two (2.1%) without this history, had toxoplasmosis titers ≥ 10 IU/ml (p = 0.166). Those with a past suicide attempt had mean toxoplasmosis titers that were significantly different (p = 0.018) from those of patients who lacked this history. An ROC analysis suggested a lower optimal threshold for distinguishing patients with and without suicide attempts (3.6 IU/ml) than that customarily used to identify seropositivity. Toxoplasmosis titers may quantify a proneness to suicidal behavior in younger individuals being treated with antidepressants.
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5
作者：
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